The efficacy and toxicity of antineoplastic antimetabolites: role of gut microbiota.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152858
Abstract: The incidence and mortality of cancer are rapidly growing all over the word. Nowadays, antineoplastic antimetabolites still play a key role in the chemotherapy of cancer. However, the interindividual variations in the efficacy and toxicity… read more here.
Keywords: efficacy toxicity; gut microbiota; antineoplastic antimetabolites; toxicity antineoplastic ... See more keywords
The effects of releasing early results from ongoing clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21116-4
Abstract: Most trials do not release interim summaries on efficacy and toxicity of the experimental treatments being tested, with this information only released to the public after the trial has ended. While early release of clinical… read more here.
Keywords: ongoing clinical; trial; effects releasing; clinical trials ... See more keywords
Alisertib: a review of pharmacokinetics, efficacy and toxicity in patients with hematologic malignancies and solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1417382
Abstract: ABSTRACT Introduction: Aurora kinases are essential mediators in cell mitosis. Amplification of these kinases can lead to the development of malignancy and may be associated with inferior survival. Alisertib is an oral aurora kinase inhibitor… read more here.
Keywords: solid tumors; pharmacokinetics efficacy; toxicity; review pharmacokinetics ... See more keywords
Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients with solid organ Transplants and Its Correlation to Efficacy and Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001054
Abstract: BACKGROUND Cytomegalovirus (CMV) causes morbidity and mortality, especially in immunocompromised patients, and is treated with (val)ganciclovir. Therapeutic drug monitoring of ganciclovir is often performed; however, clinically established target trough levels corresponding to efficacy are lacking.… read more here.
Keywords: trough levels; efficacy toxicity; therapeutic drug; efficacy ... See more keywords
The efficacy and toxicity of induction chemotherapy plus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma
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DOI: 10.1097/md.0000000000019360
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: plus concurrent; induction chemotherapy; concurrent chemoradiotherapy; chemotherapy plus ... See more keywords
Efficacy and toxicity of three concurrent chemoradiotherapy regimens in treating nasopharyngeal carcinoma: Comparison among cisplatin, nedaplatin, and lobaplatin
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031187
Abstract: Few studies directly compare efficacy and toxicity among lobaplatin, nedaplatin and cisplatin concurrently with intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC). Totally 141 treatment-naïve NPC without distant metastasis receiving IMRT concurrent with cisplatin or nedaplatin… read more here.
Keywords: nedaplatin lobaplatin; efficacy toxicity; cisplatin nedaplatin;
Efficacy and toxicity of surufatinib in neuroendocrine tumors: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13149
Abstract: The incidence and prevalence of neuroendocrine neoplasms (NENs) has increased in the US in recent decades. These are well‐vascularized tumors, but no antiangiogenic drug has been approved for treatment of extra‐pancreatic NENs. The aim is… read more here.
Keywords: efficacy; surufatinib; efficacy toxicity; meta analysis ... See more keywords
MADET: a Manually Curated Knowledge Base for Microbiomic Effects on Efficacy and Toxicity of Anticancer Treatments
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DOI: 10.1128/spectrum.02116-22
Abstract: Human microbiota plays an important role in mediating drug efficacy and toxicity in anticancer treatment. In this work, we developed a comprehensive online database, which documents over 480 microbiota-drug associations manually curated from 26 research… read more here.
Keywords: efficacy toxicity; database; microbiota drug; drug associations ... See more keywords
Efficacy and toxicity according to hormone therapy used in the CHHiP trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.6_suppl.316
Abstract: 316Background: CHHiP (CRUK/06/016) is a multicentre randomised controlled trial which investigated the use of moderately hypofractionated radiotherapy (RT) dose schedules for treatment of localised... read more here.
Keywords: trial; therapy used; according hormone; toxicity according ... See more keywords
Comparison of the efficacy and toxicity of anti-PD-1 monoclonal antibodies (nivolumab versus pembrolizumab) in treatment of patients with metastatic melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e21514
Abstract: e21514 Background: Anti-programmed cell death-1 antibodies (anti-PD-1) have become a standard treatment option for melanoma patients. Currently, two anti-PD-1 antibodies are registered in the treatment of melanoma patients: nivolumab and pembrolizumab. Nivolumab is a human… read more here.
Keywords: melanoma; efficacy toxicity; treatment; nivolumab pembrolizumab ... See more keywords
Influencing Factors of the Pharmacokinetic Characters on Nanopharmaceutics.
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738505666161214142755
Abstract: BACKGROUND Nano-pharmaceutics have been actively studied for the encapsulation and targeted delivery of drugs to improve the treatment strategies for various diseases. Because of the size, nano-pharmaceutics show some special characteristics of pharmacokinetics (PK). There… read more here.
Keywords: factors pharmacokinetic; influencing factors; nano pharmaceutics; efficacy toxicity ... See more keywords