The efficacy and toxicity of antineoplastic antimetabolites: role of gut microbiota.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152858
Abstract: The incidence and mortality of cancer are rapidly growing all over the word. Nowadays, antineoplastic antimetabolites still play a key role in the chemotherapy of cancer. However, the interindividual variations in the efficacy and toxicity… read more here.
Keywords: efficacy toxicity; gut microbiota; antineoplastic antimetabolites; toxicity antineoplastic ... See more keywords
The effects of releasing early results from ongoing clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21116-4
Abstract: Most trials do not release interim summaries on efficacy and toxicity of the experimental treatments being tested, with this information only released to the public after the trial has ended. While early release of clinical… read more here.
Keywords: ongoing clinical; trial; effects releasing; clinical trials ... See more keywords
Alisertib: a review of pharmacokinetics, efficacy and toxicity in patients with hematologic malignancies and solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1417382
Abstract: ABSTRACT Introduction: Aurora kinases are essential mediators in cell mitosis. Amplification of these kinases can lead to the development of malignancy and may be associated with inferior survival. Alisertib is an oral aurora kinase inhibitor… read more here.
Keywords: solid tumors; pharmacokinetics efficacy; toxicity; review pharmacokinetics ... See more keywords
Do CYP2D6 polymorphisms affect the efficacy and toxicity of flecainide? A cohort study
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.522
Abstract: The CYP2D6 enzyme, coded by the CYP2D6 gene, is the primary metabolic pathway for flecainide.(1,2) Over the years, studies on how different variants of this gene affect flecainide metabolism and efficacy have yielded contradictory results.(3–7)… read more here.
Keywords: toxicity flecainide; efficacy toxicity; toxicity; cohort study ... See more keywords
Therapeutic Drug Monitoring of Ganciclovir in Cytomegalovirus-Infected Patients with solid organ Transplants and Its Correlation to Efficacy and Toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001054
Abstract: BACKGROUND Cytomegalovirus (CMV) causes morbidity and mortality, especially in immunocompromised patients, and is treated with (val)ganciclovir. Therapeutic drug monitoring of ganciclovir is often performed; however, clinically established target trough levels corresponding to efficacy are lacking.… read more here.
Keywords: trough levels; efficacy toxicity; therapeutic drug; efficacy ... See more keywords
The efficacy and toxicity of induction chemotherapy plus concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000019360
Abstract: Supplemental Digital Content is available in the text read more here.
Keywords: plus concurrent; induction chemotherapy; concurrent chemoradiotherapy; chemotherapy plus ... See more keywords
Efficacy and toxicity of three concurrent chemoradiotherapy regimens in treating nasopharyngeal carcinoma: Comparison among cisplatin, nedaplatin, and lobaplatin
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031187
Abstract: Few studies directly compare efficacy and toxicity among lobaplatin, nedaplatin and cisplatin concurrently with intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC). Totally 141 treatment-naïve NPC without distant metastasis receiving IMRT concurrent with cisplatin or nedaplatin… read more here.
Keywords: nedaplatin lobaplatin; efficacy toxicity; cisplatin nedaplatin;
Efficacy and toxicity of surufatinib in neuroendocrine tumors: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13149
Abstract: The incidence and prevalence of neuroendocrine neoplasms (NENs) has increased in the US in recent decades. These are well‐vascularized tumors, but no antiangiogenic drug has been approved for treatment of extra‐pancreatic NENs. The aim is… read more here.
Keywords: efficacy; surufatinib; efficacy toxicity; meta analysis ... See more keywords
MADET: a Manually Curated Knowledge Base for Microbiomic Effects on Efficacy and Toxicity of Anticancer Treatments
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02116-22
Abstract: Human microbiota plays an important role in mediating drug efficacy and toxicity in anticancer treatment. In this work, we developed a comprehensive online database, which documents over 480 microbiota-drug associations manually curated from 26 research… read more here.
Keywords: efficacy toxicity; database; microbiota drug; drug associations ... See more keywords
Efficacy and toxicity of lurbinectedin in subsequent systemic therapy of extensive-stage small cell lung cancer: a meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-13104-w
Abstract: This study aimed to systematically analyze the efficacy and toxicity of lurbinectedin as a second-line or subsequent treatment for extensive-stage small cell lung cancer (ES-SCLC). Candidate studies were identified in PubMed, Embase, Cochrane Library, ClinicalTrials.gov,… read more here.
Keywords: toxicity lurbinectedin; efficacy toxicity; analysis; meta analysis ... See more keywords
The impact of different cervical planning target volume designs on efficacy and toxicity in nasopharyngeal carcinoma: a single-center retrospective study
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-13865-y
Abstract: In nasopharyngeal carcinoma (NPC) patients, two radiation target delineation patterns are used for the cervical lymph node area. This study compares the efficacy and toxicity of two radiation target volume delineation patterns for planning target… read more here.
Keywords: target volume; planning target; efficacy toxicity; nasopharyngeal carcinoma ... See more keywords