The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α.
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DOI: 10.1021/acs.biochem.9b00891
Abstract: The serine/threonine protein kinase casein kinase 1α (CK1α) functions as a negative regulator of Wnt signaling, phosphorylating β-catenin at serine 45 (P-S45) to initiate its eventual ubiquitin-mediated degradation. We previously showed that the repurposed, FDA-approved… read more here.
Keywords: ck1; wnt; efficiency kcat; pyrvinium enhances ... See more keywords