pH‐Responsive Polymer Nanoparticles for Efficient Delivery of Cas9 Ribonucleoprotein With or Without Donor DNA
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202110618
Abstract: Clustered regularly interspaced short palindromic repeat (CRISPR)‐associated protein 9 (Cas9) may offer new therapeutics for genetic diseases through gene disruption via nonhomologous end joining (NHEJ) or gene correction via homology‐directed repair (HDR). However, clinical translation… read more here.
Keywords: responsive polymer; efficient delivery; donor dna; cas9 ribonucleoprotein ... See more keywords
Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c05083
Abstract: Nanoneedles are a useful tool for delivering exogenous biomolecules to cells. Although therapeutic applications have been explored, the mechanism regarding how cells interact with nanoneedles remains poorly studied. Here, we present a new approach for… read more here.
Keywords: cell; efficient delivery; delivery biological; biological cargos ... See more keywords
Efficient Delivery of Therapeutic siRNA with Nanoparticles Induces Apoptosis in Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanomaterials"
DOI: 10.1155/2018/4719790
Abstract: Gene silencing using small interfering RNA (siRNA) has shown significant potential in the treatment of cancer. Herein, we developed the lipid-polymer hybrid nanoparticles (PEG-LP/siRNA NPs) for siRNA delivery. The cell viability assay indicated that PEG-LP/siRNA… read more here.
Keywords: peg sirna; efficient delivery; cancer; sirna nps ... See more keywords
Needs assessment of community health workers to enhance efficient delivery of their services for community case management of malaria in Kenya
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03640-2
Abstract: Background Malaria continues to be the leading cause of morbidity and mortality in Africa. Community Case Management of malaria (CCMm) which is undertaken by engaging Community Health Workers (CHWs) to effectively address management of malaria… read more here.
Keywords: malaria; community; efficient delivery; enhance efficient ... See more keywords
PEI-Coated Fe3O4 Nanoparticles Enable Efficient Delivery of Therapeutic siRNA Targeting REST into Glioblastoma Cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19082230
Abstract: Glioblastomas (GBM) are the most frequent brain tumors lacking efficient treatment. The increasingly elucidated gene targets make siRNA-based gene therapy a promising anticancer approach, while an efficient delivery system is urgently needed. Here, polyethyleneimine (PEI)-coated… read more here.
Keywords: efficient delivery; coated fe3o4; pei coated; rest ... See more keywords
Lignin as a Natural Carrier for the Efficient Delivery of Bioactive Compounds: From Waste to Health
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27113598
Abstract: Lignin is a fascinating aromatic biopolymer with high valorization potentiality. Besides its extensive value in the biorefinery context, as a renewable source of aromatics lignin is currently under evaluation for its huge potential in biomedical… read more here.
Keywords: lignin; carrier; efficient delivery; carrier efficient ... See more keywords