Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides
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DOI: 10.1002/ejoc.201900399
Abstract: An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained… read more here.
Keywords: pipecolic amides; synthesis; three component; efficient diastereoselective ... See more keywords