Efficient Gene Delivery Based on Guanidyl‐Nucleic Acid Molecular Interactions
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202004783
Abstract: Low transfection efficacy of non‐viral gene vectors restricts their applications. In this paper, N1,N3‐dicarbamimidoyl‐5‐methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions of an aryl ring.… read more here.
Keywords: pva hydrogel; molecular interactions; bgg dna; bgg ... See more keywords
A Branched Tripeptide with an Anion‐Binding Motif as a New Delivery Carrier for Efficient Gene Transfection
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800728
Abstract: Branched and dendrimeric cationic peptides have shown better transfection efficiency than linear peptides, owing to their superior capacity for inducing DNA condensation. We have designed and synthesized two analogously guanidinocarbonylpyrrole‐substituted (GCP‐substituted) branched cationic tripeptides that… read more here.
Keywords: transfection; efficient gene; branched tripeptide; tripeptide anion ... See more keywords
Development of a VP28-pseudotyped baculovirus expression system for efficient gene transfer in penaeid shrimps
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.736741
Abstract: Abstract Both efficient gene transfer and expression tools and suitable reporter genes are lacking for penaeid shrimps and their isolated cells. In this study a VP28-pseudotyped insect baculovirus expression system: Bacmid-GUS/VP28, carrying a reporter gene… read more here.
Keywords: expression; vp28; gene; gene transfer ... See more keywords
A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.04.003
Abstract: The RNA-guided endonuclease Cas9 has applied as an efficient gene-editing method in malaria parasite Plasmodium. However, the size (4.2 kb) of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for genome editing in… read more here.
Keywords: malaria parasite; gene editing; efficient gene; plasmodium ... See more keywords
Layered Double Hydroxide Nanoparticles for Efficient Gene Delivery for Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00434
Abstract: The use of cationic polymer based gene delivery vectors has several limitations such as low transfection efficiency, high toxicity, and inactivation by serum. The present work provides an inorganic based nanocarrier for efficient gene delivery… read more here.
Keywords: treatment; vehicle; efficient gene; gene delivery ... See more keywords
A Facile-Synthesized Star Polycation Constructed as a Highly Efficient Gene Vector in Pest Management
Sign Up to like & getrecommendations! Published in 2019 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.9b00004
Abstract: Gene vectors have been extensively applied in various fields. However, the high economic cost of gene vectors limits their development and application, and there is an urgent demand for developing highly efficient gene vectors with… read more here.
Keywords: polycation; pest management; gene; gene vector ... See more keywords
Highly efficient gene release in spatiotemporal precision approached by light and pH dual responsive copolymers† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01494a
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc01494a
Abstract: Triblock copolymer, PEG-b-PDMAEMA-b-PPy, has been shown as an ideal carrier with remarkable siRNA condensation, high stability, efficient gene release, and negligible cytotoxicity for gene delivery. read more here.
Keywords: release spatiotemporal; efficient gene; gene; gene release ... See more keywords
Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1604681
Abstract: ABSTRACT Introduction Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention… read more here.
Keywords: gene vectors; delivery; efficient gene; gene delivery ... See more keywords
Metallohelix vectors for efficient gene delivery via cationic DNA nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1277
Abstract: Abstract The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids… read more here.
Keywords: dna; delivery; gene delivery; metallohelix vectors ... See more keywords
Efficient Gene Knockout in Salivary Gland Epithelial Explant Cultures
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221128201
Abstract: We have developed methods to achieve efficient CRISPR-Cas9–mediated gene knockout in ex vivo mouse embryonic salivary epithelial explants. Salivary epithelial explants provide a valuable model for characterizing cell signaling, differentiation, and epithelial morphogenesis, but research… read more here.
Keywords: efficient gene; knockout salivary; salivary epithelial; gene knockout ... See more keywords
Efficient gene expression signature for a breast cancer immuno-subtype.
Sign Up to like & getrecommendations! Published in 2021 at "PloS one"
DOI: 10.1371/journal.pone.0245215
Abstract: MOTIVATION AND BACKGROUND The patient's immune system plays an important role in cancer pathogenesis, prognosis and susceptibility to treatment. Recent work introduced an immune related breast cancer. This subtyping is based on the expression profiles… read more here.
Keywords: breast cancer; efficient gene; expression; signature ... See more keywords