Apolipoprotein M promotes cholesterol uptake and efflux from mouse macrophages
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13157
Abstract: Apolipoprotein M (ApoM) exhibits various anti‐atherosclerotic functions as a component of high‐density lipoprotein (HDL) particles. Scavenger receptor class B type I (SR‐BI) is a classic HDL receptor that mediates selective cholesterol uptake and enhances the… read more here.
Keywords: hdl; mouse macrophages; cholesterol uptake; apom ... See more keywords
Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin‐Resistant Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700233
Abstract: Quaternary ammonium compounds (QACs) are commonly used antiseptics that are now known to be subject to bacterial resistance. The prevalence and mechanisms of such resistance, however, remain underexplored. We investigated a variety of QACs, including… read more here.
Keywords: efflux pumps; efflux; staphylococcus aureus; resistance ... See more keywords
A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7454-2_12
Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.
Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords
Changes in efflux pump activity of Clostridium beijerinckii throughout ABE fermentation
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-11072-2
Abstract: Abstract Pumping toxic substances through a cytoplasmic membrane by protein transporters known as efflux pumps represents one bacterial mechanism involved in the stress response to the presence of toxic compounds. The active efflux might also… read more here.
Keywords: abe fermentation; efflux; pump activity; efflux pump ... See more keywords
Wetland Soil Co2 Efflux Along a Latitudinal Gradient of Spatial and Temporal Complexity
Sign Up to like & getrecommendations! Published in 2018 at "Estuaries and Coasts"
DOI: 10.1007/s12237-018-0442-3
Abstract: Foundation plant species play an important functional role in modifying microenvironment through vegetation structure and by influencing soil properties. Mangroves and salt marsh differ in vegetation structure, yet offer similar ecosystem services. This work aimed… read more here.
Keywords: soil; efflux; latitudinal gradient; co2 efflux ... See more keywords
Short-term effects of biochar on soil CO2 efflux in boreal Scots pine forests
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Forest Science"
DOI: 10.1007/s13595-020-00960-2
Abstract: Key message During the first summer, wood biochar amendments increased soil temperature, pH, and soil CO 2 effluxes in a xeric boreal Scots pine forest. The increase of soil CO 2 efflux could be largely… read more here.
Keywords: soil; biochar; temperature; efflux ... See more keywords
Inhibition of blood-brain barrier efflux transporters promotes seizure in pregnant rats: Role of circulating factors
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.07.017
Abstract: Seizure-provoking factors circulate late in gestation during normal pregnancy, but do not readily gain access to the brain due to the protective nature of the blood-brain barrier. In particular, efflux transporters are powerful ATP-driven pumps… read more here.
Keywords: efflux; brain; brain barrier; blood brain ... See more keywords
Involvement of intestinal efflux and metabolic instability in the pharmacokinetics of platycodin D in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2017.05.005
Abstract: We aimed to investigate the underlying mechanisms for low bioavailability of Platycodin D (PD) in rats. The bioavailability of PD was 1.89% with different half-lives depending on the administration route (2.14 ± 0.18 h for intravenous injection vs… read more here.
Keywords: administration; platycodin rats; upper ileum; involvement intestinal ... See more keywords
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114231
Abstract: Chemotherapy is an important means of cancer treatment. However, overexpression of efflux transporters (including but not limited to P-gp and BCRP) can lead to resistance to cancer chemotherapy. Multiple-target inhibitors of efflux transporter can be… read more here.
Keywords: efflux transporter; resistance; absorption paclitaxel; efflux ... See more keywords
4-HNE induces proinflammatory cytokines of human retinal pigment epithelial cells by promoting extracellular efflux of HSP70.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107792
Abstract: Oxidative stress and subsequent chronic inflammation result in dysfunction of the retinal pigment epithelium (RPE) and represent therapeutic targets in the context of age-related macular degeneration (AMD). However, molecular mechanisms that linked oxidative stress and… read more here.
Keywords: hsp70; production; rpe cells; efflux ... See more keywords
Adhesion force sensing and activation of a membrane-bound sensor to activate nisin efflux pumps in Staphylococcus aureus under mechanical and chemical stresses.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2017.10.024
Abstract: Nisin-associated-sensitivity-response-regulator (NsaRS) in Staphylococcus aureus is important for its adhesion to surfaces and resistance against antibiotics, like nisin. NsaRS consists of an intra-membrane-located sensor NsaS and a cytoplasmatically-located response-regulator NsaR, which becomes activated upon receiving… read more here.
Keywords: nisin; adhesion; force; efflux ... See more keywords