Moderate Renal Impairment Does Not Impact the Ability of CSL112 (Apolipoprotein A‐I [Human]) to Enhance Cholesterol Efflux Capacity
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DOI: 10.1002/jcph.1337
Abstract: CSL112 (apolipoprotein A‐I [human]) is a novel intravenous formulation of plasma‐derived apolipoprotein A‐I (apoA‐I) that enhances cholesterol efflux capacity. Renal impairment is a common comorbidity in acute myocardial infarction patients and is associated with impaired… read more here.
Keywords: moderate renal; csl112; renal impairment; efflux capacity ... See more keywords
CORONARY PLAQUE BURDEN IS ASSOCIATED WITH CHOLESTEROL EFFLUX CAPACITY PARTIALLY MEDIATED BY THE HEMATOPOIETIC SYSTEM IN PSORIASIS
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)32085-6
Abstract: Psoriasis, a chronic inflammatory skin disease, is associated with heightened FDG-uptake in the bone marrow (BM) by FDG/PET-CT concomitant with increased non-calcified coronary plaque burden (NCB) by CCTA. Additionally, psoriasis patients have reduced cholesterol efflux… read more here.
Keywords: psoriasis; efflux capacity; cholesterol efflux; plaque burden ... See more keywords
Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0183-7
Abstract: Berberine, berberrubine, thalifendine, demethyleneberberine, jatrorrhizine, and columbamine are six natural protoberberine alkaloid (PA) compounds that display extensive pharmacological properties and share the same protoberberine molecular skeleton with only slight substitution differences. The oral delivery of… read more here.
Keywords: binding affinities; capacity; six compounds; glycoprotein mediated ... See more keywords
Development and validation of novel automatable assay for cholesterol efflux capacity
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience Reports"
DOI: 10.1042/bsr20221519
Abstract: Abstract During the past decade, evaluation of high-density lipoprotein (HDL) functionality has been well studied for predicting cardiovascular disease (CVD) risk. Cholesterol efflux capacity (CEC) is the strongest candidate as the biomarker out of various… read more here.
Keywords: ilg method; method; magnetic beads; cholesterol efflux ... See more keywords
Effect of CSL112 (apolipoprotein A‐I [human]) on cholesterol efflux capacity in Japanese subjects: Findings from a phase I study and a cross‐study comparison
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13361
Abstract: CSL112 (apolipoprotein A‐I [apoA‐I, human]) is a novel drug in development to reduce the risk of recurrent cardiovascular events following acute myocardial infarction by increasing cholesterol efflux capacity (CEC). This phase I study aimed to… read more here.
Keywords: csl112; efflux capacity; cholesterol efflux; japanese subjects ... See more keywords
Effect of a PCSK9 inhibitor and a statin on cholesterol efflux capacity: A limitation of current cholesterol‐lowering treatments?
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13766
Abstract: Cellular cholesterol efflux is a key step in reverse cholesterol transport that may impact on atherosclerotic cardiovascular risk. The process may be reliant on the availability of apolipoprotein (apo) B‐100‐containing lipoproteins to accept cholesterol from… read more here.
Keywords: effect pcsk9; cholesterol efflux; cholesterol; pcsk9 inhibitor ... See more keywords
Cholesterol efflux capacity of high‐density lipoprotein was not associated with cognitive decline and brain structures in older people with diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13875
Abstract: To examine the association between cholesterol efflux capacity (CEC) of serum high‐density lipoprotein (HDL) and cognitive function and brain structures in older people with diabetes mellitus. read more here.
Keywords: structures older; high density; brain structures; cholesterol efflux ... See more keywords
Relationship of Para and Perirenal Fat and High-Density Lipoprotein and Its Function in Patients with Type 2 Diabetes Mellitus
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DOI: 10.1155/2021/9286492
Abstract: Background Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension. We aimed to assess the relationship… read more here.
Keywords: hdl level; efflux capacity; para perirenal; serum ... See more keywords
Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin)
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DOI: 10.1161/circulationaha.116.025678
Abstract: Background: Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity,… read more here.
Keywords: particle number; efflux capacity; cholesterol; cholesterol efflux ... See more keywords
CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology and Therapeutics"
DOI: 10.1177/10742484221121507
Abstract: Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112 is intended to improve CEC and thereby prevent early… read more here.
Keywords: csl112; apoa; plasma; cholesterol efflux ... See more keywords
Cholesterol efflux capacity does not associate with coronary calcium, plaque vulnerability, and telomere length in healthy octogenarians[S]
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DOI: 10.1194/jlr.p079525
Abstract: Several studies have revealed that traditional risk factors are less effective in predicting CVD risk in the elderly, suggesting the need to identify new biomarkers. Here, we evaluated the association between serum cholesterol efflux capacity… read more here.
Keywords: risk; telomere length; cholesterol efflux; efflux capacity ... See more keywords