Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin‐Resistant Staphylococcus aureus
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DOI: 10.1002/cbic.201700233
Abstract: Quaternary ammonium compounds (QACs) are commonly used antiseptics that are now known to be subject to bacterial resistance. The prevalence and mechanisms of such resistance, however, remain underexplored. We investigated a variety of QACs, including… read more here.
Keywords: efflux pumps; efflux; staphylococcus aureus; resistance ... See more keywords
A Transcriptomic Approach to Identify Novel Drug Efflux Pumps in Bacteria.
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DOI: 10.1007/978-1-4939-7454-2_12
Abstract: The core genomes of most bacterial species include a large number of genes encoding putative efflux pumps. The functional roles of most of these pumps are unknown, however, they are often under tight regulatory control… read more here.
Keywords: novel drug; identify novel; drug efflux; efflux pumps ... See more keywords
Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system
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DOI: 10.1007/s12275-019-8520-1
Abstract: Tripartite efflux pumps and the type I secretion system of Gram-negative bacteria are large protein complexes that span the entire cell envelope. These complexes expel antibiotics and other toxic substances or transport protein toxins from… read more here.
Keywords: secretion system; pumps type; type secretion; efflux pumps ... See more keywords
Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.08.004
Abstract: The widespread use of antibiotics created selective pressure for the emergence of strains that would persist despite antibiotic toxicity. The bacterial resistance mechanisms are several, with efflux pumps being one of the main ones. These… read more here.
Keywords: efflux pumps; staphylococcus aureus; tannic acid;
Molecular Insights into Compound-Transporter Interactions: The Case of Inhibitors of Gram-Negative Bacteria Efflux Pumps
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DOI: 10.1016/j.bpj.2016.11.1483
Abstract: The Escherichia coli AcrAB-TolC efflux pump is the archetype of the Resistance-Nodulation-cell Division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type efflux pumps is a major factor in multidrug resistance (MDR), which makes these polyspecific… read more here.
Keywords: gram negative; compound transporter; negative bacteria; molecular insights ... See more keywords
A Comprehensive Review on Pharmacology of Efflux Pumps and their Inhibitors in Antibiotic Resistance.
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DOI: 10.1016/j.ejphar.2021.174151
Abstract: The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic application over time. In recent decades, antibiotic resistance has become one of the most severe threats to public health. It can… read more here.
Keywords: pharmacology; resistance; antibiotic resistance; efflux pumps ... See more keywords
Repurposing bioactive aporphine alkaloids as efflux pump inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.104371
Abstract: Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with efflux pump inhibitors may help to restore… read more here.
Keywords: roemerine; pump inhibitors; efflux pump; bmra ... See more keywords
The role of efflux pumps in Bacteroides fragilis resistance to antibiotics.
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DOI: 10.1016/j.micres.2018.02.007
Abstract: The resistance of Bacteroides fragilis to the most antimicrobial agents has been reported in the world. Identification of the microbial resistance mechanisms can play an important role in controlling these resistances. Currently, B. fragilis is… read more here.
Keywords: resistance antibiotics; role efflux; bacteroides fragilis; resistance ... See more keywords
Reconstitution of the activity of RND efflux pumps: a "bottom-up" approach.
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DOI: 10.1016/j.resmic.2017.11.004
Abstract: Efflux pumps are systems devoted to the extrusion of noxious compounds. In this review, we discuss the various strategies that have thus far been undertaken for the investigation of efflux pumps after reconstitution into liposomes.… read more here.
Keywords: activity rnd; rnd efflux; efflux pumps; efflux ... See more keywords
Computer simulations of the activity of RND efflux pumps.
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DOI: 10.1016/j.resmic.2017.12.001
Abstract: The putative mechanism by which bacterial RND-type multidrug efflux pumps recognize and transport their substrates is a complex and fascinating enigma of structural biology. How a single protein can recognize a huge number of unrelated… read more here.
Keywords: activity rnd; computer simulations; rnd efflux; efflux pumps ... See more keywords
Sequence- and structure-based computational analyses of Gram-negative tripartite efflux pumps in the context of bacterial membranes.
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DOI: 10.1016/j.resmic.2018.01.002
Abstract: Gram-negative multidrug resistance currently presents a serious threat to public health with infections effectively rendered untreatable. Multiple molecular mechanisms exist that cause antibiotic resistance and in addition, the last three decades have seen slowing rates… read more here.
Keywords: gram negative; negative tripartite; resistance; sequence structure ... See more keywords