Examining P‐gp efflux kinetics guided by the BDDCS ‐ Rational selection of in vitro assay designs and mathematical models
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.03.005
Abstract: ABSTRACT The generation of reliable kinetic parameters to describe P‐glycoprotein (P‐gp) activity is essential for predicting the impact of efflux transport on gastrointestinal drug absorption. The compound‐specific selection of in vitro assay designs and ensuing… read more here.
Keywords: assay designs; vitro assay; selection vitro; selection ... See more keywords
Effect of proinflammatory cytokine IL-6 on efflux transport of rebamipide in Caco-2 cells
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DOI: 10.1080/00498254.2016.1229085
Abstract: Abstract 1. Effect of IL-6, a pro-inflammatory cytokine, on efflux transport of rebamipide, an antiulcer drug, was investigated in Caco-2 cells. 2. Rebamipide had a greater basal-to-apical than apical-to-basal transport rate. Efflux transport of rebamipide was inhibited… read more here.
Keywords: transport rebamipide; efflux transport; transport; cytokine efflux ... See more keywords
Multidrug Resistance–Associated Protein 3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
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DOI: 10.1124/dmd.119.089193
Abstract: Curcumin, a major polyphenol present in turmeric, is predominantly converted to curcumin-O-glucuronide (COG) in enterocytes and hepatocytes via glucuronidation. COG is a principal metabolite of curcumin in plasma and feces. It appears that the efflux… read more here.
Keywords: cog; curcumin glucuronide; multidrug resistance; efflux transport ... See more keywords