Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3346-4
Abstract: Treatment with doxorubicin (dox) and emodin, separately and together, under normoxic and hypoxia-like conditions induced by CoCl2, led to greater intracellular compound accumulation over 10 h post-addition in the presence of CoCl2 in lung adenocarcinoma (A549)… read more here.
Keywords: lung adenocarcinoma; accumulation; colorectal carcinoma; dox emodin ... See more keywords
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114231
Abstract: Chemotherapy is an important means of cancer treatment. However, overexpression of efflux transporters (including but not limited to P-gp and BCRP) can lead to resistance to cancer chemotherapy. Multiple-target inhibitors of efflux transporter can be… read more here.
Keywords: efflux transporter; resistance; absorption paclitaxel; efflux ... See more keywords
Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00371
Abstract: Toxicokinetics (TK) of ionic compounds in the toxico-/pharmacological model zebrafish embryo (Danio rerio) depend on absorption, distribution, metabolism, and elimination (ADME) processes. Previous research indicated involvement of transport proteins in the TK of the anionic… read more here.
Keywords: oatp1d1; efflux transporter; bromoxynil zebrafish; cellular efflux ... See more keywords
Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00435
Abstract: Hepatic and extrahepatic tissues participate in xenobiotic detoxication, carcinogen activation, prodrug processing, and estrogen regulation through UDP-glucuronosyltransferases (UGTs/Ugts) and sulfotransferases (SULTs/Sults). Wild-type (WT) and efflux transporter knockout (KO) FVB mice have been commonly used to… read more here.
Keywords: ugts sults; efflux transporter; mice; major metabolic ... See more keywords
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03129-6
Abstract: Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects. Synergistic drug combinations… read more here.
Keywords: neuroblastoma; drug; lapatinib; efflux transporter ... See more keywords
Restraining the multidrug efflux transporter STY4874 of Salmonella Typhi by reserpine and plant extracts
Sign Up to like & getrecommendations! Published in 2019 at "Letters in Applied Microbiology"
DOI: 10.1111/lam.13196
Abstract: Efflux‐mediated multidrug resistance is a well‐known phenomenon facilitated by multidrug resistant (MDR) transporters. One of the approaches to counteract efflux‐mediated resistance is the use of MDR pump inhibitors, and thus be used in combination with… read more here.
Keywords: typhi; plant; pump; sty4874 ... See more keywords
P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1182571
Abstract: The situation of opioid abuse has deteriorated in recent years. In 2019, 49,860 people died from opioid overdoses in the USA alone, a 6-fold increase since 2000 (Ko et al., 2020). Of particular concern is… read more here.
Keywords: clearance; efflux transporter; side; methadone ... See more keywords