Glycyrrhetinic Acid Accelerates the Clearance of Triptolide through P‐gp In Vitro
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DOI: 10.1002/ptr.5831
Abstract: Triptolide (TP) is an active ingredient isolated from Tripterygium wilfordii Hook. f. (TWHF), which is a traditional herbal medicine widely used for the treatment of rheumatoid arthritis and autoimmune disease in the clinic. However, its… read more here.
Keywords: glycyrrhetinic acid; clearance triptolide; acid accelerates; accelerates clearance ... See more keywords
Activation of adenosine receptors modulates the efflux transporters in brain capillaries and restores the anticonvulsant effect of carbamazepine in carbamazepine resistant rats developed by window-pentylenetetrazole kindling
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146516
Abstract: Up-regulation of efflux transporters in brain capillaries may lead to the decreased therapeutic efficacy of antiepileptic drugs in patients with Drug Resistant Epilepsy. Adenosine receptor activation in brain capillaries can modulate blood-brain barrier permeability by… read more here.
Keywords: resistant rats; brain capillaries; activation; adenosine ... See more keywords
Challenges with the precise prediction of ABC-transporter interactions for improved drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2018.1493454
Abstract: ABSTRACT Introduction: Given that membrane efflux transporters can influence a drug’s pharmacokinetics, efficacy and safety, identifying potential substrates and inhibitors of these transporters is a critical element in the drug discovery and development process. Additionally,… read more here.
Keywords: drug; substrate inhibitor; efflux transporters; drug discovery ... See more keywords
Regulation of Placental Efflux Transporters during Pregnancy Complications
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DOI: 10.1124/dmd.121.000449
Abstract: The placenta is essential for regulating the exchange of solutes between the maternal and fetal circulations. As a result, the placenta offers support and protection to the developing fetus by delivering crucial nutrients and removing… read more here.
Keywords: placental efflux; barrier; pregnancy complications; regulation placental ... See more keywords
Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae
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DOI: 10.1128/mbio.00338-20
Abstract: One mechanism behind drug resistance is altered export out of the cell. This work is a multifaceted analysis of membrane efflux transporters in the human fungal pathogen A. fumigatus. Bioinformatics evidence infers that there is… read more here.
Keywords: transporter; drug; drug resistance; efflux ... See more keywords
Interactions Between Emodin and Efflux Transporters on Rat Enterocyte by a Validated Ussing Chamber Technique
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00646
Abstract: Emodin, a major active anthraquinone, frequently interacts with other drugs. As changes of efflux transporters on intestine are one of the essential reasons why the drugs interact with each other, a validated Ussing chamber technique… read more here.
Keywords: emodin efflux; ussing chamber; chamber technique; interactions emodin ... See more keywords
The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates
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DOI: 10.3389/fphar.2021.802539
Abstract: Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The resulting glucuronide and sulfate conjugates are generally considered inactive and safe. They may, however, be the most prominent drug-related material in… read more here.
Keywords: transporters disposition; sulfate conjugates; disposition glucuronide; efflux transporters ... See more keywords
A Non-Nutritive Feeding Intervention Alters the Expression of Efflux Transporters in the Gastrointestinal Tract
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13111789
Abstract: Intestinal interactions with nutrients, xenobiotics and endogenous hormones can influence the expression of clinically relevant membrane transporters. These changes in the gastrointestinal (GI) physiology can in turn affect the absorption of numerous drug substrates. Several… read more here.
Keywords: feeding intervention; nutritive feeding; intervention alters; non nutritive ... See more keywords