Hippocampal neurogenesis promotes effortful responding but does not regulate effort‐based choice
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23472
Abstract: A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human‐relevant behavioral traits is still missing. We used the hGFAP‐TK rat model… read more here.
Keywords: hippocampal neurogenesis; based choice; neurogenesis; effort based ... See more keywords
Effort-based decision-making impairment in patients with clinically-stabilized first-episode psychosis and its relationship with amotivation and psychosocial functioning
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2019.03.006
Abstract: Effort-based decision-making has recently been proposed as a potential mechanism contributing to motivational deficits (amotivation) in psychotic disorder. Previous research has identified altered effort allocation in chronic schizophrenia, but produced mixed results regarding its relationship… read more here.
Keywords: based decision; amotivation; effort based; decision making ... See more keywords
Effort-based decision-making in ultra-high-risk for psychosis and bipolar disorder.
Sign Up to like & getrecommendations! Published in 2024 at "Psychological medicine"
DOI: 10.1017/s003329172400134x
Abstract: BACKGROUND Effort-based decision-making has been proposed as a potential mechanism contributing to transdiagnostic motivational deficits in psychotic disorder and bipolar disorder. However, very limited information is available about deficits in effort-cost-decision-making in the early stages… read more here.
Keywords: effort based; based decision; disorder; effort ... See more keywords
A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Psychiatry"
DOI: 10.1038/s41380-024-02726-y
Abstract: Motivation levels vary across individuals, yet the underlying mechanisms driving these differences remain elusive. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and the anterior insula (aIns) play crucial roles in effort-based decision-making. Here, we… read more here.
Keywords: effort based; based decision; decision making; dacc ... See more keywords
Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male mice
Sign Up to like & getrecommendations! Published in 2025 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-025-02140-0
Abstract: Antidepressant-induced apathy syndrome is reported in a high number of patients. It is characterised by loss of motivation for daily activities and emotional blunting. It has a negative impact on quality of life and treatment… read more here.
Keywords: task; effort based; treatment; effort ... See more keywords
Neurometabolic predictors of mental effort in the frontal cortex
Sign Up to like & getrecommendations! Published in 2025 at "Translational Psychiatry"
DOI: 10.1038/s41398-025-03554-6
Abstract: Motivation drives individuals to overcome costs to achieve desired outcomes, such as rewards or avoidance of punishment, with significant variability across individuals. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) and anterior insula are key… read more here.
Keywords: effort based; based decision; effort; mental effort ... See more keywords
Increasing motivation in effort-based decision-making tasks: effects of salience and reward expectancy manipulations.
Sign Up to like & getrecommendations! Published in 2021 at "Cognitive neuropsychiatry"
DOI: 10.1080/13546805.2021.2007068
Abstract: BACKGROUND A significant proportion of patients with affective and psychotic disorders show a marked reduction in goal-directed behaviour, which is also reflected in the behavioural outcomes of effort-based decision-making paradigms. The factors underlying this reduction… read more here.
Keywords: based decision; reward expectancy; effort based; decision making ... See more keywords
Apathy in small vessel cerebrovascular disease is associated with deficits in effort-based decision making
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab013
Abstract: Abstract Patients with small vessel cerebrovascular disease frequently suffer from apathy, a debilitating neuropsychiatric syndrome, the underlying mechanisms of which remain to be established. Here we investigated the hypothesis that apathy is associated with disrupted… read more here.
Keywords: decision; based decision; effort based; small vessel ... See more keywords
Aberrant effort-based reward dynamics in anhedonia.
Sign Up to like & getrecommendations! Published in 2024 at "Cerebral cortex"
DOI: 10.1093/cercor/bhae193
Abstract: Anhedonia is a transdiagnostic symptom and associated with a spectrum of reward deficits among which the motivational dysfunction is poorly understood. Previous studies have established the abnormal cost-benefit trade-off as a contributor to motivational deficits… read more here.
Keywords: effort based; effort; reward; effort expenditure ... See more keywords
Understanding the Association Between Negative Symptoms and Performance on Effort-Based Decision-Making Tasks: The Importance of Defeatist Performance Beliefs
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbx156
Abstract: Effort-based decision-making paradigms are increasingly utilized to gain insight into the nature of motivation deficits. Research has shown associations between effort-based decision making and experiential negative symptoms; however, the associations are not consistent. The current… read more here.
Keywords: based decision; negative symptoms; effort based; decision making ... See more keywords
An Effort-Based Reward Approach for Allocating Load Shedding Amount in Networked Microgrids Using Multiagent System
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Industrial Informatics"
DOI: 10.1109/tii.2019.2929284
Abstract: An effort-based reward approach is proposed in this article for the allocation of load shedding amount in interconnected microgrids. In this article, effort is defined as the relative contribution of a microgrid to the network… read more here.
Keywords: effort; based reward; effort based; reward approach ... See more keywords