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   Articles with "efv" as a keyword



Efavirenz is associated with altered fronto-striatal function in HIV+ adolescents

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recommendations! Published in 2019 at "Journal of NeuroVirology"

DOI: 10.1007/s13365-019-00764-9

Abstract: Neurotoxicity associated with the antiretroviral efavirenz (EFV) has been documented in HIV-infected adults, but there are no data on the impact of EFV on brain function in adolescents. We investigated potential alterations in fronto-striatal function… read more here.

Keywords: hiv adolescents; hiv; inhibition; fronto striatal ... See more keywords

Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals

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recommendations! Published in 2018 at "Infectious Diseases and Therapy"

DOI: 10.1007/s40121-018-0194-1

Abstract: IntroductionTenofovir disoproxil fumarate (TDF) has been associated with greater incidences of bone complications, which might be modified by some concomitantly administered antiretrovirals, possibly by their effect on tenofovir concentrations. We compared bone adverse outcomes among… read more here.

Keywords: ftc; bone; tdf ftc; efv ... See more keywords

Reply to the letter to editor "Impact of epicardial adipose tissue volume quantified by non-contrast electrocardiogram-gated computed tomography on ergonovine-induced epicardial coronary artery spasm".

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recommendations! Published in 2017 at "International journal of cardiology"

DOI: 10.1016/j.ijcard.2016.11.293

Abstract: We thank Dr. Ohyama and colleagues for their interest in our study We agree with Dr. Ohyama's suggestion that we need to clarify the [1], which demonstrated that increased epicardial fat volume (EFV)was associatedwith ergonovine-induced… read more here.

Keywords: volume; efv; adipose tissue; ergonovine induced ... See more keywords
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Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials

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recommendations! Published in 2021 at "Drug Development and Industrial Pharmacy"

DOI: 10.1080/03639045.2021.1934860

Abstract: Abstract Objective To perform the solid-state characterization and the in vitro-in vivo correlation (IVIVC) of three batches of efavirenz (EFV) active pharmaceutical ingredients. Significance EFV is an effective anti-HIV drug. Due to the poor aqueous… read more here.

Keywords: batches efavirenz; vitro dissolution; efv; characterization vitro ... See more keywords

Quantification of Efavirenz Hydroxymetabolites in Human Plasma Using LC-HRMS/MS

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recommendations! Published in 2024 at "Therapeutic Drug Monitoring"

DOI: 10.1097/ftd.0000000000001173

Abstract: Supplemental Digital Content is Available in the Text. Background: Efavirenz (EFV) is a drug used to treat HIV. Low plasma concentrations of EFV result in suboptimal viral suppression, whereas high concentrations can cause adverse neuropsychiatric… read more here.

Keywords: human plasma; method; quantification efavirenz; efv ... See more keywords

Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers

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recommendations! Published in 2022 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-022-02315-8

Abstract: Efavirenz (EFV) with a booster dose of ritonavir (RTV) (EFV-RTV) inhibits the metabolism of EFV and improves its bioavailability. However, inadequate organ perfusion with surface permeability glycoprotein (P-gp) efflux sustains the viable HIV. Hence, the… read more here.

Keywords: ppg4er; booster dose; efv; bioavailability ... See more keywords

Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study)

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recommendations! Published in 2019 at "PLoS Medicine"

DOI: 10.1371/journal.pmed.1002895

Abstract: Background The global transition to use of dolutegravir (DTG) in WHO-preferred regimens for HIV treatment is limited by lack of knowledge on use in pregnancy. Here we assessed the relationship between drug concentrations (pharmacokinetics, PK),… read more here.

Keywords: suppression; plasma; trial; dtg ... See more keywords

From Antiretroviral to Antibacterial: Deep-Learning-Accelerated Repurposing and In Vitro Validation of Efavirenz Against Gram-Positive Bacteria

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recommendations! Published in 2025 at "Molecules"

DOI: 10.3390/molecules30142925

Abstract: The repurposing potential of Efavirenz (EFV), a clinically established non-nucleoside reverse transcriptase inhibitor, was comprehensively evaluated for its in vitro antibacterial effect either alone or in combination with other antibacterial agents on several Gram-positive clinical… read more here.

Keywords: deep learning; antiretroviral antibacterial; learning accelerated; gram positive ... See more keywords