Efavirenz is associated with altered fronto-striatal function in HIV+ adolescents
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DOI: 10.1007/s13365-019-00764-9
Abstract: Neurotoxicity associated with the antiretroviral efavirenz (EFV) has been documented in HIV-infected adults, but there are no data on the impact of EFV on brain function in adolescents. We investigated potential alterations in fronto-striatal function… read more here.
Keywords: hiv adolescents; hiv; inhibition; fronto striatal ... See more keywords
Tenofovir-Associated Bone Adverse Outcomes among a US National Historical Cohort of HIV-Infected Veterans: Risk Modification by Concomitant Antiretrovirals
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DOI: 10.1007/s40121-018-0194-1
Abstract: IntroductionTenofovir disoproxil fumarate (TDF) has been associated with greater incidences of bone complications, which might be modified by some concomitantly administered antiretrovirals, possibly by their effect on tenofovir concentrations. We compared bone adverse outcomes among… read more here.
Keywords: ftc; bone; tdf ftc; efv ... See more keywords
Reply to the letter to editor "Impact of epicardial adipose tissue volume quantified by non-contrast electrocardiogram-gated computed tomography on ergonovine-induced epicardial coronary artery spasm".
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.293
Abstract: We thank Dr. Ohyama and colleagues for their interest in our study We agree with Dr. Ohyama's suggestion that we need to clarify the [1], which demonstrated that increased epicardial fat volume (EFV)was associatedwith ergonovine-induced… read more here.
Keywords: volume; efv; adipose tissue; ergonovine induced ... See more keywords
Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials
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DOI: 10.1080/03639045.2021.1934860
Abstract: Abstract Objective To perform the solid-state characterization and the in vitro-in vivo correlation (IVIVC) of three batches of efavirenz (EFV) active pharmaceutical ingredients. Significance EFV is an effective anti-HIV drug. Due to the poor aqueous… read more here.
Keywords: batches efavirenz; vitro dissolution; efv; characterization vitro ... See more keywords
Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers
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DOI: 10.1208/s12249-022-02315-8
Abstract: Efavirenz (EFV) with a booster dose of ritonavir (RTV) (EFV-RTV) inhibits the metabolism of EFV and improves its bioavailability. However, inadequate organ perfusion with surface permeability glycoprotein (P-gp) efflux sustains the viable HIV. Hence, the… read more here.
Keywords: ppg4er; booster dose; efv; bioavailability ... See more keywords
Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study)
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DOI: 10.1371/journal.pmed.1002895
Abstract: Background The global transition to use of dolutegravir (DTG) in WHO-preferred regimens for HIV treatment is limited by lack of knowledge on use in pregnancy. Here we assessed the relationship between drug concentrations (pharmacokinetics, PK),… read more here.
Keywords: suppression; plasma; trial; dtg ... See more keywords