Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity.
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DOI: 10.1021/acschembio.6b01040
Abstract: To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 "braking" dominates motility. Loop-5 inhibitors (monastrol, STLC, ispinesib, and filanesib)… read more here.
Keywords: microtubule stability; contrasting effects; eg5; inhibitors contrasting ... See more keywords
Non‐canonical functions of the mitotic kinesin Eg5
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DOI: 10.1111/1759-7714.12792
Abstract: Kinesins are widely expressed, microtubule‐dependent motors that play vital roles in microtubule‐associated cellular activities, such as cell division and intracellular transport. Eg5, also known as kinesin‐5 or kinesin spindle protein, is a member of the… read more here.
Keywords: eg5; non canonical; mitotic kinesin; kinesin ... See more keywords
TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5
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DOI: 10.3389/fonc.2022.855139
Abstract: Tumor necrosis factor receptor associated factor 4 (TRAF4) is a RING domain E3 ubiquitin ligase that mediates the ubiquitination of various proteins and plays an important role in driving tumor progression. By studying the relationship… read more here.
Keywords: eg5; breast cancer; ubiquitination; traf4 ... See more keywords
Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC
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DOI: 10.3389/fonc.2022.965455
Abstract: The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear. We exploited HCT116 cancer cell line to select… read more here.
Keywords: loop; resistant clones; resistance; stlc ... See more keywords
S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma.
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DOI: 10.3892/ol.2018.8755
Abstract: Eg5 is a member of the kinesin-5 family. It is involved in the formation of the bipolar spindle and serves a crucial role in mitosis; meaning that mitotic activation may serve as a chemotherapeutic strategy.… read more here.
Keywords: trityl cysteine; chemotherapeutic strategy; eg5 inhibitor; eg5 ... See more keywords