Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation
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DOI: 10.18632/oncotarget.17207
Abstract: Eg5 is a kinesin spindle protein that controls chromosomal segregation in mitosis and is thus a critical drug target for cancer therapy. We report the discovery of a potent, selective inhibitor of Eg5 designated YL001.… read more here.
Keywords: cancer; inhibits tumor; yl001; eg5 inhibitor ... See more keywords
S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology letters"
DOI: 10.3892/ol.2018.8755
Abstract: Eg5 is a member of the kinesin-5 family. It is involved in the formation of the bipolar spindle and serves a crucial role in mitosis; meaning that mitotic activation may serve as a chemotherapeutic strategy.… read more here.
Keywords: trityl cysteine; chemotherapeutic strategy; eg5 inhibitor; eg5 ... See more keywords