The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
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DOI: 10.1111/jnc.15842
Abstract: The accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small molecules targeting such structures and promoting their degradation may have therapeutic… read more here.
Keywords: egcg directly; directly targets; amyloid aggregates; lysosomal degradation ... See more keywords