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   Articles with "egf" as a keyword



Recombinant Expression of a Ready‐to‐Use EGF Variant Equipped With a Single Conjugation Site for Click‐Chemistry

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recommendations! Published in 2025 at "Engineering in Life Sciences"

DOI: 10.1002/elsc.70015

Abstract: The epidermal growth factor (EGF) receptor is commonly targeted in cancer therapy because it is overexpressed in many malignant cells. However, a general problem is to couple the targeting moieties and the drug molecules in… read more here.

Keywords: chemistry; single conjugation; egf; egf variant ... See more keywords

Roles for HB‐EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth

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recommendations! Published in 2019 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.3596

Abstract: HB‐EGF, a member of the EGF superfamily, plays important roles in development and tissue regeneration. However, its functions in skeletal stem cells and skeleton development and growth remain poorly understood. Here, we used the Cre/LoxP… read more here.

Keywords: mesenchymal stromal; egf; proliferation; bone ... See more keywords

CREB activity is required for epidermal growth factor‐induced mouse cumulus expansion

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recommendations! Published in 2019 at "Molecular Reproduction and Development"

DOI: 10.1002/mrd.23285

Abstract: The release of a fertilizable oocyte from the ovary is dependent upon the expansion of the cumulus cells. The expansion requires cooperation between epidermal growth factor (EGF) family peptide‐activated mitogen‐activated protein kinase (MAPK)3/1 and oocyte… read more here.

Keywords: expansion; egf; creb; factor ... See more keywords

RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity

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recommendations! Published in 2017 at "International Journal of Gerontology"

DOI: 10.1016/j.ijge.2017.03.006

Abstract: Summary Background Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family and is involved in various diseases including cancers. Aptamers are synthetic oligonucleotides (RNA or DNA) that fold into unique… read more here.

Keywords: growth factor; egf; high affinity; aptamer ... See more keywords

Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: a possible role of EGF.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2021.120069

Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of… read more here.

Keywords: egf; venlafaxine; venlafaxine induced; steroidogenesis ... See more keywords

Multivalent Ligand-Nanoparticle Conjugates Amplify Reactive Oxygen Species Second Messenger Generation and Enhance Epidermal Growth Factor Receptor Phosphorylation.

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recommendations! Published in 2022 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.2c00335

Abstract: The epidermal growth factor (EGF) receptor (EGFR) is heterogeneously distributed on the cellular surface and enriched in clusters with diameters of tens of nanometers. Multivalent presentation of EGF ligand on nanoparticles (NPs) provides an approach… read more here.

Keywords: reactive oxygen; oxygen species; epidermal growth; egf ... See more keywords

The effect of heat stress on the epidermal growth factor (EGF)-mediated intracellular signaling, and changes cell behavior on swine testicular cell.

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recommendations! Published in 2022 at "Animal biotechnology"

DOI: 10.1080/10495398.2022.2126370

Abstract: At present, high environmental temperature is the main factor endangering animal production, growth and development. Therefore, the harmful effects of heat stress led by hot environment on livestock have attracted much attention. In this work,… read more here.

Keywords: egf; cell; heat stress; effect ... See more keywords

Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2027172

Abstract: ABSTRACT Uric acid (UA) is the main metabolite of the human body. Although UA is only a product of metabolism, it is important biological regulator. Epidermal growth factor (EGF) has important biological functions. However, so… read more here.

Keywords: epidermal growth; concentration; egf; activity ... See more keywords

The clearance of EGF by tumor-associated macrophages is suppressed by chemotherapeutic agent cisplatin

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz269.043

Abstract: Abstract Background Tumor-associated macrophages (TAMs) are a major component of innate immunity supporting primary tumor growth and metastasis. Chemotherapy is one of the main treatment strategies for solid tumors, while chemoresistance is the major limitation… read more here.

Keywords: associated macrophages; egf; cancer; tumor ... See more keywords

A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry

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recommendations! Published in 2022 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msac270

Abstract: Abstract Asymmetries are essential for proper organization and function of organ systems. Genetic studies in bilaterians have shown signaling through the Nodal/Smad2 pathway plays a key, conserved role in the establishment of body asymmetries. Although… read more here.

Keywords: cfc gene; egf cfc; small change; egf ... See more keywords

Enhanced Skin Wound Healing Through Chemically Modified Messenger RNA Encoding Epidermal Growth Factor (EGF)

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recommendations! Published in 2025 at "International Wound Journal"

DOI: 10.1111/iwj.70143

Abstract: Efficient wound healing remains a formidable medical challenge in clinical practice, due to the prevalence of skin defects arising from diverse etiological factors. It is indisputable that epidermal growth factor (EGF) plays a pivotal role… read more here.

Keywords: egf; wound healing; growth factor; skin ... See more keywords