Roles for HB‐EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3596
Abstract: HB‐EGF, a member of the EGF superfamily, plays important roles in development and tissue regeneration. However, its functions in skeletal stem cells and skeleton development and growth remain poorly understood. Here, we used the Cre/LoxP… read more here.
Keywords: mesenchymal stromal; egf; proliferation; bone ... See more keywords
CREB activity is required for epidermal growth factor‐induced mouse cumulus expansion
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23285
Abstract: The release of a fertilizable oocyte from the ovary is dependent upon the expansion of the cumulus cells. The expansion requires cooperation between epidermal growth factor (EGF) family peptide‐activated mitogen‐activated protein kinase (MAPK)3/1 and oocyte… read more here.
Keywords: expansion; egf; creb; factor ... See more keywords
RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Gerontology"
DOI: 10.1016/j.ijge.2017.03.006
Abstract: Summary Background Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family and is involved in various diseases including cancers. Aptamers are synthetic oligonucleotides (RNA or DNA) that fold into unique… read more here.
Keywords: growth factor; egf; high affinity; aptamer ... See more keywords
Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: a possible role of EGF.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120069
Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of… read more here.
Keywords: egf; venlafaxine; venlafaxine induced; steroidogenesis ... See more keywords
Multivalent Ligand-Nanoparticle Conjugates Amplify Reactive Oxygen Species Second Messenger Generation and Enhance Epidermal Growth Factor Receptor Phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00335
Abstract: The epidermal growth factor (EGF) receptor (EGFR) is heterogeneously distributed on the cellular surface and enriched in clusters with diameters of tens of nanometers. Multivalent presentation of EGF ligand on nanoparticles (NPs) provides an approach… read more here.
Keywords: reactive oxygen; oxygen species; epidermal growth; egf ... See more keywords
The effect of heat stress on the epidermal growth factor (EGF)-mediated intracellular signaling, and changes cell behavior on swine testicular cell.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2126370
Abstract: At present, high environmental temperature is the main factor endangering animal production, growth and development. Therefore, the harmful effects of heat stress led by hot environment on livestock have attracted much attention. In this work,… read more here.
Keywords: egf; cell; heat stress; effect ... See more keywords
Uric acid, as a double-edged sword, affects the activity of epidermal growth factor (EGF) on human umbilical vein endothelial cells by regulating aging process
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2027172
Abstract: ABSTRACT Uric acid (UA) is the main metabolite of the human body. Although UA is only a product of metabolism, it is important biological regulator. Epidermal growth factor (EGF) has important biological functions. However, so… read more here.
Keywords: epidermal growth; concentration; egf; activity ... See more keywords
The clearance of EGF by tumor-associated macrophages is suppressed by chemotherapeutic agent cisplatin
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz269.043
Abstract: Abstract Background Tumor-associated macrophages (TAMs) are a major component of innate immunity supporting primary tumor growth and metastasis. Chemotherapy is one of the main treatment strategies for solid tumors, while chemoresistance is the major limitation… read more here.
Keywords: associated macrophages; egf; cancer; tumor ... See more keywords
A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac270
Abstract: Abstract Asymmetries are essential for proper organization and function of organ systems. Genetic studies in bilaterians have shown signaling through the Nodal/Smad2 pathway plays a key, conserved role in the establishment of body asymmetries. Although… read more here.
Keywords: cfc gene; egf cfc; small change; egf ... See more keywords
Caught in the “Akt”: Cross-talk between EphA2 and EGFR through the Akt-PIKfyve axis maintains cellular sensitivity to EGF
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aau1207
Abstract: EphA activation upon cell-cell contact balances EGFR degradation and recycling to ensure sustained responsiveness to EGF (Stallaert et al., in 31 July 2018 issue). Activation of EGFR (epidermal growth factor receptor) and Eph receptor often… read more here.
Keywords: cross talk; egfr; talk epha2; egf ... See more keywords
HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/6170936
Abstract: HB-EGF is essential for uterine decidualization, but its antioxidant function remains largely unclear. Here, we found that HB-EGF promoted the proliferation of stromal cells followed by the accelerated transition of the cell cycle from G1… read more here.
Keywords: egf; cell; uterine decidualization; oxidative stress ... See more keywords