Activation of Endosome-Associated Inert EGF Receptor Following Internalization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7219-7_8
Abstract: Our current understanding of endosomal signaling is incomplete given our inability to generate endosomal signals in isolation from plasma membrane signals. We present a novel method to specifically activate epidermal growth factor (EGF) receptor (EGFR)… read more here.
Keywords: endosome associated; egf receptor; internalization; endosomal signaling ... See more keywords
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03845-3
Abstract: Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17.… read more here.
Keywords: adam17; egf receptor; irhd; homology domain ... See more keywords
Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06011
Abstract: Alpha-ACTN4, a member of alpha-actinin family is critical for cell motility through its regulated binding of actin filaments. We previously found that EGF exposure of cells triggers the tyrosyl-phosphorylation of ACTN4 in fibroblasts that dramatically… read more here.
Keywords: actn4 egf; phosphorylation; actn4; egf receptor ... See more keywords
MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-5128-5
Abstract: BackgroundAgarose encapsulated murine renal adenocarcinoma cells (RENCA macrobeads) are currently being investigated in clinical trials as a treatment for therapy-resistant metastatic colorectal cancer. We have previously demonstrated the capacity of RENCA macrobeads to produce diffusible… read more here.
Keywords: egf receptor; tumor cells; renca macrobeads; cancer ... See more keywords
Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0177761
Abstract: ErbB (Erythroblastic Leukemia Viral Oncogene Homolog) receptor tyrosine kinases are critical for tissue development and maintenance, and frequently become oncogenic when mutated or overexpressed. In vitro analysis of ErbB receptor kinases can be difficult because… read more here.
Keywords: characterization; egf receptor; water; receptor ... See more keywords
Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00541
Abstract: Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although the molecular mechanism is not fully understood, H. pylori is known to modulate the Erk pathway for induction… read more here.
Keywords: egf receptor; expression; pylori induced; gastrin expression ... See more keywords
Role of EGF Receptor Regulatory Networks in the Host Response to Viral Infections
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.820355
Abstract: In this review article, we will first provide a brief overview of EGF receptor (EGFR) structure and function, and its importance as a therapeutic target in epithelial carcinomas. We will then compare what is currently… read more here.
Keywords: role; egfr; egf receptor; viral infections ... See more keywords