IQGAP1 scaffolding links Phosphoinositide Kinases to Cytoskeletal Reorganization.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical journal"
DOI: 10.1016/j.bpj.2022.01.018
Abstract: IQGAP1 is a multi-domain scaffold protein that coordinates the direction and impact of multiple signaling pathways by scaffolding its various binding partners. However, the spatial and temporal resolution of IQGAP1 scaffolding remains unclear. Here, we… read more here.
Keywords: iqgap1 scaffolding; iqgap1; cytoskeletal reorganization; cytoskeletal changes ... See more keywords
Abstract 2506: Flotillin 2 negatively regulates EGFR phosphorylation and Cbl-mediated ubiquitination and degradation
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DOI: 10.1158/1538-7445.am2018-2506
Abstract: EGF receptor (EGFR) signaling is dysregulated by gene amplification or activating mutations of the EGFR in a variety of human malignancies. Activation of the EGFR by EGF leads to recruitment of the ubiquitin ligase Cbl,… read more here.
Keywords: degradation; cbl; flot2; egf stimulation ... See more keywords