EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15125
Abstract: Following gut epithelial damage, epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signalling triggers Drosophila intestinal stem cells to produce enteroblasts (EBs) and enterocytes (ECs) that regenerate the gut. As EBs differentiate into ECs, they become… read more here.
Keywords: egfr dependent; regeneration; dependent tor; growth ... See more keywords
EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Letter.
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DOI: 10.1158/0008-5472.can-16-2456
Abstract: Hsu and colleagues reported on EGF/EGFR–triggered activation of regulated intramembrane proteolysis (RIP) of EpCAM that induces an EMT phenotype ([1][1]). This finding is of utmost interest, as it might explain contradicting effects of EpCAM on… read more here.
Keywords: egfr dependent; dependent regulated; intramembrane proteolysis; epcam ... See more keywords
Intron 1–Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins
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DOI: 10.1158/1541-7786.mcr-19-0747
Abstract: The epidermal growth factor receptor (EGFR) is overexpressed in numerous solid tumors and is the subject of extensive therapeutic efforts. Much of the research on EGFR is focused on protein dynamics and downstream signaling; however,… read more here.
Keywords: regulation; intron; egfr dependent; transcription ... See more keywords