Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation
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DOI: 10.5483/bmbrep.2018.51.1.163
Abstract: Non-small-cell lung cancer (NSCLC) is commonly caused by a mutation in the epidermal growth factor receptor (EGFR) and subsequent aberrant EGFR signaling with uncontrolled kinase activity. A deletion mutation in EGFR exon 19 is frequently… read more here.
Keywords: egfr; egfr downregulation; mutant egfr; lung cancer ... See more keywords