CD166 promotes cancer stem cell-like phenotype via the EGFR/ERK1/2 pathway in the nasopharyngeal carcinoma cell line CNE-2R.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118983
Abstract: AIMS The present study aimed to investigate the role and underlying mechanisms of CD166 in cancer stem cell-like (CSCs) phenotype of the radioresistant nasopharyngeal carcinoma cell CNE-2R. MAIN METHODS Established CD166-shRNA- CNE-2R cell line by… read more here.
Keywords: egfr erk1; cne; cd166; nasopharyngeal carcinoma ... See more keywords
HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation
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DOI: 10.18632/oncotarget.21190
Abstract: In normal colon, claudin-2 expression is restricted to the crypt bottom containing the undifferentiated and proliferative colonocytes. Claudin-2 expression is also upregulated in colorectal cancer (CRC) and promotes carcinogenesis. However, cellular mechanism/s regulated by increased… read more here.
Keywords: egfr erk1; claudin expression; expression; differentiation ... See more keywords
Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway
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DOI: 10.2147/dddt.s346376
Abstract: Purpose It is well known that inflammation plays a key role in complex pathological progressions of alcohol-associated liver disease (ALD). To date, effective therapy for ALD is lacking. P2Y2 receptor (P2Y2R), a G protein-coupled P2Y… read more here.
Keywords: p2y2r; inflammation; liver; egfr erk1 ... See more keywords
Anti-Invasive and Anti-Migratory Effects of Ononin on Human Osteosarcoma Cells by Limiting the MMP2/9 and EGFR-Erk1/2 Pathway
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DOI: 10.3390/cancers15030758
Abstract: Simple Summary Osteosarcoma is the most prevalent orthotopic bone tumor. Due to its high metastatic properties, it has become the leading cause of cancer death worldwide. At this time, there is no effective treatment for… read more here.
Keywords: cell; osteosarcoma; anti; egfr erk1 ... See more keywords