Pembrolizumab and chemotherapy in non‐small cell lung cancer with EGFR ex20ins mutation: A case report
Sign Up to like & getrecommendations! Published in 2021 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14101
Abstract: The efficacy of immunotherapy in non‐small cell lung cancer (NSCLC) with uncommon epidermal growth factor receptor (EGFR) mutations is not well clarified, even though immunotherapy has brought revolutionary improvements in EGFR wild‐type NSCLC. In addition,… read more here.
Keywords: egfr ex20ins; case; non small; cancer ... See more keywords
Abstract 5199: JNJ-61186372, an EGFR-cMet bispecific antibody, in EGFR Exon 20 insertion-driven advanced non-small cell lung cancer (NSCLC)
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DOI: 10.1158/1538-7445.am2020-5199
Abstract: PURPOSE: Although EGFR exon20 insertion (ex20ins) mutations account for 4~12 % of EGFR mutant NSCLC patients, there is no effective and selectable anticancer drugs targeting ex20ins mutations so far due to various variant mutations in… read more here.
Keywords: jnj; egfr ex20ins; jnj 372; cell ... See more keywords
Real-world treatment outcome of advanced Chinese NSCLC EGFR exon 20 insertion patients.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.9043
Abstract: 9043 Background: Treatment outcome of advanced EGFR exon20 insertion (ex20ins) patients with 1st- or 2nd-line chemotherapy and EGFR TKIs remains limited. Methods: Retrospective real-world analysis of clinical, molecular, and treatment outcome of a web-based patient… read more here.
Keywords: treatment; treatment outcome; line; egfr ... See more keywords
EGFR exon 20 insertion mutations in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Translational cancer research"
DOI: 10.21037/tcr.2020.03.10
Abstract: Mutations in the epidermal growth factor receptor (EGFR) gene are the most common targetable genomic drivers of non-small cell lung cancer (NSCLC). 90% of the EGFR mutations comprise of EGFR exon 19 deletion and exon… read more here.
Keywords: egfr; egfr exon; egfr ex20ins; non small ... See more keywords
Real-world clinical treatment outcomes in Chinese non-small cell lung cancer with EGFR exon 20 insertion mutations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.949304
Abstract: Background EGFR exon 20 insertions (EGFR ex20ins) constitute a heterogeneous subset of EGFR-activating alterations. However, the effectiveness of standard therapy in patients with EGFR ex20ins remains poor. Methods In our study, we retrospectively collected next-generation… read more here.
Keywords: nsclc patients; egfr exon; egfr ex20ins; generation ... See more keywords