FHL1 promotes glioblastoma aggressiveness through regulating EGFR expression
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13955
Abstract: The four‐and‐a‐half LIM domain protein 1 (FHL1) plays a key role in multiple cancers. Here, we characterized its role in glioblastoma (GBM), the most common and incurable form of brain cancer. Overexpression of FHL1 promotes… read more here.
Keywords: glioblastoma aggressiveness; promotes glioblastoma; egfr expression; fhl1 promotes ... See more keywords
The growing role of biology in the treatment of glioblastoma: no more one kind of disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2417-9
Abstract: IDH-wild-type and GBM IDH-mutated. Frequently, some entities, different from GBM, demonstrate EGFR amplification, TERT+, mutation of P53, PTEN and NF1. These diseases are characterized by a particularly poor glioblastoma-like prognosis, even in the absence of… read more here.
Keywords: gbm; treatment; biology; egfr expression ... See more keywords
Oncologic Outcomes in Metastatic Colorectal Cancer with Regorafenib with FOLFIRI as a Third- or Fourth-Line Setting123
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.12.003
Abstract: BACKGROUND: To evaluate the efficacy and toxicities of regorafenib plus irinotecan, dose-escalated on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping, in previously heavily treated metastatic colorectal cancer (mCRC) and the prognostic values of… read more here.
Keywords: metastatic colorectal; colorectal cancer; egfr expression; regorafenib folfiri ... See more keywords
Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61688-7
Abstract: Sporadic colorectal cancer (sCRC) is the third most frequent cancer worldwide and the second most common cause of cancer-related deaths (mainly due metastatic dissemination). We investigated the immunohistochemical expression of frequently altered proteins in primary… read more here.
Keywords: sporadic colorectal; copy number; expression; egfr expression ... See more keywords
Abstract 671: Prognostic importance of EGFR expression and Kras gene mutations in gallbladder carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-671
Abstract: Gallbladder carcinomas involve multiple cascades of oncogenes like EGFR and Kras. Activation of Kras downstream pathways predict the sensitivity to anti EGFR treatment. In 2012, for the first time it was established that GBC and… read more here.
Keywords: kras gene; expression; egfr expression; prognostic importance ... See more keywords
A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000479397
Abstract: Background/Aims: MicroRNAs (miRNAs) have been consistently demonstrated to be involved in colorectal cancer as either tumour oncogenes or tumour suppressors. However, the detailed role of miR-520a-3p in colorectal cancer remains poorly understood. Methods: Quantitative RT-PCR… read more here.
Keywords: role mir; mir 520a; colorectal cancer; egfr expression ... See more keywords
Analysis of the relative copy numbers of TP63, YAP1 and KMT2D genetic loci and EGFR expression in orthotopic patient-derived xenografts of cardioesophageal cancer in immunodeficient mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e15033
Abstract: e15033 Background: Cardioesophageal cancer is a common tumor affecting the cardiac stomach and lower esophagus. Tumor heterogeneity is important, since it can cause the ineffectiveness of chemotherapy and radiotherapy due to individual characteristics of the… read more here.
Keywords: cancer; cardioesophageal cancer; egfr expression; copy numbers ... See more keywords
Investigating the clinical significance of EGFR expression using machine learning in a series of Iraqi patients with triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicine and Life"
DOI: 10.25122/jml-2021-0401
Abstract: Breast cancer is a heterogeneous disease with a distinct profile of the expression of each tumor. Triple-negative breast cancer (TNBC) is a molecular subtype of breast cancer characterized by an aggressive clinical behavior linked to… read more here.
Keywords: breast cancer; egfr expression; iraqi patients; expression ... See more keywords
The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133074
Abstract: Simple Summary Prostate cancer is one of the most common malignancies in men. Current therapies are initially effective but resistance often develops, leading to tumor recurrence and death. Further research on new players, mechanisms involved… read more here.
Keywords: prostate cancer; egfr expression; dhrs7; expression ... See more keywords
The Use of a Non-Conventional Long-Lived Gallium Radioisotope 66Ga Improves Imaging Contrast of EGFR Expression in Malignant Tumours Using DFO-ZEGFR:2377 Affibody Molecule
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13020292
Abstract: Epidermal growth factor receptor (EGFR) is overexpressed in many malignancies. EGFR-targeted therapy extends survival of patients with disseminated cancers. Radionuclide molecular imaging of EGFR expression would make EGFR-directed treatment more personalized and therefore more efficient.… read more here.
Keywords: dfo zegfr; zegfr 2377; egfr expression; fold higher ... See more keywords
Higher nuclear EGFR expression is a better predictor of survival in rectal cancer patients following neoadjuvant chemoradiotherapy than cytoplasmic EGFR expression
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2018.9756
Abstract: The aim of the present study was to investigate the prognostic value of cytoplasmic (−C) and nuclear epidermal growth factor receptor (EGFR-N) expression in rectal cancer patients following neoadjuvant concurrent chemoradiotherapy (CCRT). A total of… read more here.
Keywords: cancer patients; expression; egfr expression; rectal cancer ... See more keywords