Inter-lobe Motions Allosterically Regulate the Structure and Function of EGFR Kinase.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.06.007
Abstract: Protein kinases play important roles in cellular signaling and have been one of the best studied drug targets. The kinase domain of epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that has been… read more here.
Keywords: kinase; egfr kinase; lobe; inter lobe ... See more keywords
2D-QSAR Modeling and Molecular Docking Studies on 1H-Pyrazole-1-carbothioamide Derivatives as EGFR Kinase Inhibitors
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DOI: 10.1021/acsomega.0c01323
Abstract: Epidermal growth factor receptor (EGFR) kinase has been commonly associated with cancers such as lung, ovarian, hormone-refractory prostate, metastatic colorectal, glioblastoma, pancreatic, and breast cancers. A series of 1H-pyrazole-1-carbothioamide derivatives and their EGFR inhibitory activities… read more here.
Keywords: pyrazole carbothioamide; kinase inhibitors; kinase; derivatives egfr ... See more keywords
Lung adenocarcinoma patient with an EGFR kinase domain duplication (KDD) and the response to icotinib.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.04.162
Abstract: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related morbidity and mortality worldwide (1). Epidermal growth factor receptor ( EGFR ) mutations, as driver oncogenes, were first identified in NSCLC in 2004 (2). read more here.
Keywords: lung adenocarcinoma; adenocarcinoma patient; patient egfr; kinase domain ... See more keywords