Radiomics based on dual‐layer spectral detector CT for predicting EGFR mutation status in non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.14616
Abstract: Abstract Objective To explore the value of dual‐layer spectral computed tomography (DLCT)‐based radiomics for predicting epidermal growth factor receptor (EGFR) mutation status in patients with non‐small cell lung cancer (NSCLC). Methods DLCT images and clinical… read more here.
Keywords: mutation status; egfr mutation; layer spectral; dual layer ... See more keywords
Real‐world analysis of the prognostic value of EGFR mutation detection in plasma ctDNA from patients with advanced non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5582
Abstract: The plasma sample has emerged as a promising surrogate sample for EGFR mutation detection in advanced non‐small cell lung cancer (NSCLC). In clinical practice, whether EGFR variants in baseline plasma ctDNA of advanced NSCLC can… read more here.
Keywords: mutation detection; cancer; non small; egfr mutation ... See more keywords
Possible new mechanisms of primary drug resistance in NSCLC with EGFR mutation treated with Osimertinib
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DOI: 10.1002/iub.70002
Abstract: In this study, a patient with lung adenocarcinoma harboring an EGFR mutation exhibited primary resistance to the targeted EGFR inhibitor Osimertinib after 2 months of treatment. As the disease advanced, further genetic analysis revealed the emergence… read more here.
Keywords: treatment; resistance; egfr mutation; drug resistance ... See more keywords
Association between squamous cell carcinoma antigen level and EGFR mutation status in Chinese lung adenocarcinoma patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24613
Abstract: To investigate the association between squamous cell carcinoma antigen (SCCAg) level and epidermal growth factor receptor (EGFR) mutation status in Chinese lung adenocarcinoma patients. read more here.
Keywords: cell carcinoma; mutation status; squamous cell; carcinoma antigen ... See more keywords
MRI-based radiomics analysis for predicting the EGFR mutation based on thoracic spinal metastases in lung adenocarcinoma patients.
Sign Up to like & getrecommendations! Published in 2021 at "Medical physics"
DOI: 10.1002/mp.15137
Abstract: PURPOSE This study aims to develop and evaluate multi-parametric MRI-based radiomics for preoperative identification of epidermal growth factor receptor (EGFR) mutation, which is important in treatment planning for patients with thoracic spinal metastases from primary… read more here.
Keywords: lung adenocarcinoma; egfr mutation; thoracic spinal; mri based ... See more keywords
Radiomics signature of brain metastasis: prediction of EGFR mutation status
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-020-07614-x
Abstract: To predict epidermal growth factor receptor (EGFR) mutation status in lung adenocarcinoma using MR-based radiomics signature of brain metastasis and explore the optimal MR sequence for prediction. Data from 52 patients with brain metastasis from… read more here.
Keywords: mutation status; radiomics signature; egfr mutation; signature ... See more keywords
A clinically practical radiomics-clinical combined model based on PET/CT data and nomogram predicts EGFR mutation in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "European Radiology"
DOI: 10.1007/s00330-020-07676-x
Abstract: This study aims to develop a clinically practical model to predict EGFR mutation in lung adenocarcinoma patients according to radiomics signatures based on PET/CT and clinical risk factors. This retrospective study included 583 lung adenocarcinoma… read more here.
Keywords: lung adenocarcinoma; model; pet radiomics; egfr mutation ... See more keywords
Impact of EGFR mutation on the clinical efficacy of PD-1 inhibitors in patients with pulmonary adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02889-0
Abstract: PurposeWe evaluated the predictive role of EGFR mutation on the efficacy of PD-1/PD-L1 inhibitor therapy in patients with advanced pulmonary adenocarcinoma while considering clinical factors such as PD-L1 expression, gender, and smoking status.MethodsPatients were required… read more here.
Keywords: egfr mutation; efficacy inhibitors; expression; pulmonary adenocarcinoma ... See more keywords
Predictive models for patients with lung carcinomas to identify EGFR mutation status via an artificial neural network based on multiple clinical information
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03103-x
Abstract: Purpose Epidermal growth factor receptor (EGFR) mutation testing has several limitations. Therefore, we built predictive models to determine the EGFR mutation status of patients and guide therapeutic decision-making. Methods We collected data from 320 patients… read more here.
Keywords: model; model auroc; egfr mutation; mutation status ... See more keywords
Successful treatment with an EGFR tyrosine kinase inhibitor Afatinib in a patient with combined small-cell lung Cancer with EGFR mutation
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DOI: 10.1007/s10637-018-0586-9
Abstract: SummarySmall-cell lung cancer (SCLC) combined with epidermal growth factor receptor (EGFR) mutations is extremely rare, and standard chemotherapeutic strategies have not yet been established. In the present study, we report a case of a 67-year-old… read more here.
Keywords: chemotherapy; egfr mutation; line; cell lung ... See more keywords
EGFR Mutation Testing of non-squamous NSCLC: Impact and Uptake during Implementation of Testing Guidelines in a Population-Based Registry Cohort from Northern New Zealand
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DOI: 10.1007/s11523-017-0515-4
Abstract: BackgroundSince 2013, clinical practice guidelines recommend EGFR mutation testing of non-squamous NSCLC to select advanced-stage patients for first-line treatment using EGFR-TKIs.ObjectiveWe aimed to determine population-based trends in the real-world uptake and impact in routine practice… read more here.
Keywords: egfr mutation; population based; mutation testing; population ... See more keywords