Expanding the search for significant EGFR mutations in NSCLC outside of the tyrosine kinase domain with next-generation sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-0985-3
Abstract: While conventional organization of EGFR mutations in non-small cell lung cancer (NSCLC) includes classic lesions sensitive to tyrosine kinase inhibitors (TKI) and variants localized to the tyrosine kinase domain (TKD) in exons 18–21, next-generation sequencing… read more here.
Keywords: kinase domain; tyrosine kinase; egfr mutations; extra tkd ... See more keywords
Clustering based drug-drug interaction networks for possible repositioning of drugs against EGFR mutations: Clustering based DDI networks for EGFR mutations
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.04.011
Abstract: EGFRs are a vast group of receptor tyrosine kinases playing an important role in a number of tumors, including lungs, head and neck, breast, and esophageal cancers. A couple of techniques are being used in… read more here.
Keywords: egfr mutations; clustering based; drug interaction; drug ... See more keywords
The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: A systematic review and critical appraisal.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2020.101994
Abstract: Uncommon epidermal growth factor receptor (EGFR) mutations collectively account for 10% of EGFR mutations, harboring heterogeneous molecular alterations within exons 18-21 with clinically variable responses to EGFR tyrosine kinase inhibitors (TKIs) in advanced Non-Small Cell… read more here.
Keywords: egfr mutations; factor receptor; growth factor; cancer ... See more keywords
Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.06.003
Abstract: Epidermal growth factor receptor (EGFR) mutations have been used as the strongest predictor of effectiveness of treatment with EGFR tyrosine kinase inhibitors (TKIs). Three most common EGFR mutations (L858R, exon 19 deletion, and T790M) are… read more here.
Keywords: egfr mutations; factor receptor; growth factor; picodroplet digital ... See more keywords
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113711
Abstract: EGFR mutations are an ongoing challenge in the treatment of NSCLC, and demand continuous updating of EGFR TKI drug candidates. Pyrrolopyrimidines are one group of versatile scaffolds suitable for tailored drug development. However not many… read more here.
Keywords: bioactivity; egfr mutations; kinase; pyrrolo pyrimidine ... See more keywords
Genotyping of common EGFR mutations in lung cancer patients by electrochemical biosensor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2017.12.015
Abstract: In this study, we constructed a sandwich-type biosensor to identify six common types of mutations in exon 19 of the epidermal growth factor receptor (EGFR) gene, and tested them using tissue samples from patients with… read more here.
Keywords: egfr mutations; biosensor; mutations lung; lung cancer ... See more keywords
Depression, inflammation, and epidermal growth factor receptor (EGFR) status in metastatic non-small cell lung cancer: A pilot study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychosomatic research"
DOI: 10.1016/j.jpsychores.2017.05.009
Abstract: OBJECTIVE Patients with stage IV non-small cell lung cancer (NSCLC) have high risk for depressive symptoms and major depressive disorder (MDD); however, those with epidermal growth factor receptor (EGFR) mutations may have decreased risk. The… read more here.
Keywords: depression; egfr mutations; non small; cancer ... See more keywords
Uncommon EGFR mutations in advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2017.04.016
Abstract: Molecular profiling in advanced non-small cell lung cancer (NSCLC) has allowed for the detection of actionable mutations, which has revolutionized the treatment paradigm in this highly fatal disease. Mutations involving the epidermal growth factor receptor… read more here.
Keywords: egfr; uncommon egfr; egfr mutations; lung cancer ... See more keywords
A phase II study of afatinib treatment for elderly patients with previously untreated advanced non-small-cell lung cancer harboring EGFR mutations.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.10.014
Abstract: OBJECTIVE The efficacy and safety of afatinib in elderly patients with EGFR-mutated non-small-cell lung cancer (NSCLC) have not been evaluated. This study aimed to assess the efficacy and safety of afatinib in elderly chemotherapy-naive patients… read more here.
Keywords: elderly patients; treatment; egfr mutations; lung cancer ... See more keywords
Effects of secondary EGFR mutations on resistance against upfront osimertinib in cells with EGFR-activating mutations in vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.10.026
Abstract: OBJECTIVES Non-small cell lung cancers (NSCLCs) that harbor activating mutations for epidermal growth factor receptor (EGFR) show remarkable initial response to EGFR-tyrosine kinase inhibitors (TKIs), but inevitably acquire resistance, half of which are due to… read more here.
Keywords: egfr mutations; egfr tkis; resistance; activating mutations ... See more keywords
Real-time PCR and targeted next-generation sequencing in the detection of low level EGFR mutations: Instructive case analyses
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2019.100901
Abstract: Background Allele specific real-time PCR and next-generation sequencing (NGS) are widely used to detect somatic mutation in non-small cell lung cancer (NSCLC). Both methods commonly use formalin-fixed paraffin-embedded (FFPE) tissues as diagnostic materials. Real-time PCR… read more here.
Keywords: time pcr; egfr mutations; real time;