Targeting the EGFR pathway shows promise for OA
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-021-00583-5
Abstract: 0123456789();: while enabling prolonged retention and high cartilage penetration. Similar to EGFR overactivation, intra-articular delivery of these TGFα-conjugated nanoparticles in the knees of mice attenuated the development of surgery-induced OA. “We are currently collaborating with… read more here.
Keywords: egfr pathway; rheumatology; pathway shows; shows promise ... See more keywords
Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-0605
Abstract: Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their mechanisms of action are mainly undocumented. Through public glioma mRNA expression data sets, we found that NEAT1 was a potential oncogene. We systematically analyzed… read more here.
Keywords: long noncoding; found neat1; regulated egfr; catenin ... See more keywords
Bax/Bcl-2 Cascade Is Regulated by the EGFR Pathway: Therapeutic Targeting of Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.869672
Abstract: Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR is involved in several cancer developments, including NSCLC. The EGFR pathway regulates the Bax/Bcl-2 cascade in NSCLC. Increasing understanding of the molecular mechanisms… read more here.
Keywords: lung; bax bcl; egfr pathway; lung cancer ... See more keywords
EGFR Pathway Expression Persists in Recurrent Glioblastoma Independent of Amplification Status
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15030670
Abstract: Simple Summary We compared gene expression in matched primary and recurrent glioblastoma samples, with a focus on those harbouring extra copies of the gene called EGFR (amplified samples). Our results show that in the setting… read more here.
Keywords: amplification; recurrent glioblastoma; egfr pathway; amplification status ... See more keywords