Abstract 2506: Flotillin 2 negatively regulates EGFR phosphorylation and Cbl-mediated ubiquitination and degradation
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DOI: 10.1158/1538-7445.am2018-2506
Abstract: EGF receptor (EGFR) signaling is dysregulated by gene amplification or activating mutations of the EGFR in a variety of human malignancies. Activation of the EGFR by EGF leads to recruitment of the ubiquitin ligase Cbl,… read more here.
Keywords: degradation; cbl; flot2; egf stimulation ... See more keywords