Characterization of MGMT and EGFR protein expression in glioblastoma and association with survival
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03358-x
Abstract: Purpose Understanding the molecular landscape of glioblastoma (GBM) is increasingly important in the age of targeted therapy. O-6-Methylguanine-DNA methyltransferase ( MGMT ) promoter methylation and EGFR amplification are markers that may play a role in… read more here.
Keywords: protein expression; mgmt; egfr protein; expression ... See more keywords
In Silico Screening of Synthetic and Natural Compounds to Inhibit the Binding Capacity of Heavy Metal Compounds against EGFR Protein of Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2941962
Abstract: Inorganic pollutant, specifically heavy metals' contamination, is a significant matter of concern and is one of the key contributors in various health disorders including cancer. However, the interaction of heavy metals (HMs) with lung cancer… read more here.
Keywords: lung cancer; natural compounds; egfr protein; drug ... See more keywords
A New Anticancer Semisynthetic Theobromine Derivative Targeting EGFR Protein: CADDD Study
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13010191
Abstract: A new lead compound has been designed as an antiangiogenic EGFR inhibitor that has the pharmacophoric characteristics to bind with the catalytic pocket of EGFR protein. The designed lead compound is a (para-chloro)acetamide derivative of… read more here.
Keywords: egfr protein; new anticancer; protein; semisynthetic theobromine ... See more keywords