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   Articles with "egfr ras" as a keyword



EGFR and Ras regulate DDX59 during lung cancer development.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.11.029

Abstract: Oncogenes EGFR and ras are frequently mutated and activated in human lung cancers. In this report, we found that both EGFR and Ras signaling can upregulate RNA helicase DDX59 in lung cancer cells. DDX59 can… read more here.

Keywords: ddx59 lung; lung cancer; egfr ras; lung ... See more keywords
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EGFR/Ras-induced CCL20 production modulates the tumour microenvironment

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recommendations! Published in 2020 at "British Journal of Cancer"

DOI: 10.1038/s41416-020-0943-2

Abstract: Background The activation of the EGFR/Ras-signalling pathway in tumour cells induces a distinct chemokine repertoire, which in turn modulates the tumour microenvironment. Methods The effects of EGFR/Ras on the expression and translation of CCL20 were… read more here.

Keywords: tumour microenvironment; production; egfr ras; ccl20 ... See more keywords

Two Main Cancer Biomarkers as Molecular Targets of Binase Antitumor Activity

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recommendations! Published in 2024 at "BioMed Research International"

DOI: 10.1155/2024/8159893

Abstract: Cancer is frequently coupled with the disturbance of key signaling pathways. Aberrant activation of the mitogen-activated protein kinase (MAPK) signaling cascade, occurring in over 85% of cancers, is mainly caused by the genetic alterations of… read more here.

Keywords: cancer; egfr ras; main cancer; two main ... See more keywords

Abstract 1841: Investigating mechanisms of tumor eradication by blocking SIAH E3 ligase, a major tumor vulnerability, in EGFR/RAS-driven human cancer

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-1841

Abstract: Introduction: Hyperactivation of the EGFR/RAS pathway is a major driver of tumorigenesis and metastasis. It has been difficult to design effective therapies contravening the compensatory EGFR/RAS downstream effector pathways to achieve curative antitumor efficacy. Seven… read more here.

Keywords: cancer; tumor vulnerability; egfr ras; tumor ... See more keywords

FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.13790

Abstract: Forkhead box D3 (FOXD3), as a transcriptional repressor, is well known to be involved in the regulation of development. Although FoxD3 is associated with several cancers, its role in colon cancer and the underlying mechanism… read more here.

Keywords: colon; ras raf; colon cancer; cancer ... See more keywords

Integrins Cooperate With the EGFR/Ras Pathway to Preserve Epithelia Survival and Architecture in Development and Oncogenesis

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.892691

Abstract: Adhesion to the extracellular matrix (ECM) is required for normal epithelial cell survival. Disruption of this interaction leads to a specific type of apoptosis known as anoikis. Yet, there are physiological and pathological situations in… read more here.

Keywords: egfr ras; cell; ras pathway; integrins cooperate ... See more keywords