Rab25-Mediated EGFR Recycling Causes Tumor Acquired Radioresistance
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DOI: 10.1016/j.isci.2020.100997
Abstract: Summary Tumor acquired radioresistance remains as the major limit in cancer radiotherapy (RT). Rab25, a receptor recycling protein, has been reported to be enhanced in tumors with aggressive phenotype and chemotherapy resistance. In this study,… read more here.
Keywords: acquired radioresistance; egfr recycling; rab25; tumor acquired ... See more keywords
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
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DOI: 10.1038/s41388-021-02017-8
Abstract: ISG15 is an ubiquitin-like modifier that is associated with reduced survival rates in breast cancer patients. The mechanism by which ISG15 achieves this however remains elusive. We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta… read more here.
Keywords: basal breast; isgylation; egfr recycling; tumour progression ... See more keywords
Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling
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DOI: 10.15252/embr.201947734
Abstract: Despite recently uncovered connections between autophagy and the endocytic pathway, the role of autophagy in regulating endosomal function remains incompletely understood. Here, we find that the ablation of autophagy‐essential players disrupts EGF‐induced endocytic trafficking of… read more here.
Keywords: autophagy facilitates; targeting early; endosomes autophagy; early endosomes ... See more keywords