EGFR Signaling Is Required for Maintaining Adult Cartilage Homeostasis and Attenuating Osteoarthritis Progression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4531
Abstract: The uppermost superficial zone of articular cartilage is the first line of defense against the initiation of osteoarthritis (OA). We previously used Col2‐Cre to demonstrate that epidermal growth factor receptor (EGFR), a tyrosine kinase receptor,… read more here.
Keywords: icko mice; cartilage; adult cartilage; egfr ... See more keywords
Activating EGFR Signaling Attenuates Osteoarthritis Development Following Loading Injury in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4717
Abstract: Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of joint function, and impaired quality of daily life in patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signaling is essential… read more here.
Keywords: ptoa; development; cartilage; injury ... See more keywords
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7599
Abstract: Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. The purpose of our study was to determine the effect of quercetin treatment on renal fibrosis and investigate… read more here.
Keywords: renal fibrosis; quercetin inhibits; egfr signaling; tubular epithelial ... See more keywords
Studying Nonproliferative Roles for Egfr Signaling in Tissue Morphogenesis Using Dorsal Closure of the Drosophila Embryo.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7219-7_16
Abstract: For several decades, genetic analysis in Drosophila has made important contributions to the understanding of signaling by Egfr. Egfr has been well characterized with regard to its oncogenic potential but is also being studied for… read more here.
Keywords: drosophila embryo; closure; egfr signaling; dorsal closure ... See more keywords
Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-017-1386-9
Abstract: BackgroundAlport syndrome (AS) is a hereditary kidney disease caused by mutation of type IV collagen. Loss of collagen network induces collapse of glomerular basement membrane (GBM) structure. The previous studies showed that upregulation of some… read more here.
Keywords: renal inflammatory; inflammatory cytokines; mouse model; egfr signaling ... See more keywords
Integrating Multiplex Single-Molecule Pull-Down (SiMPull) Data and Computational Modeling to Understand EGFR Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.11.2554
Abstract: The Epidermal Growth Factor Receptor (EGFR) plays an important role in both physiological and cancerrelated processes. To study the factors that influence EGFR phosphorylation, we have coupled single-molecule microscopy experiments with rule-based modeling of EGFR… read more here.
Keywords: egfr; single molecule; egfr signaling; grb2 ... See more keywords
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.11.016
Abstract: Triple-negative breast cancer (TNBC) patients have the worst prognosis and distant metastasis-free survival among all major subtypes of breast cancer. The poor clinical outlook is further exacerbated by a lack of effective targeted therapies for… read more here.
Keywords: fak egfr; egfr signaling; breast cancer; metastasis ... See more keywords
Pilose antler peptide protects osteoblasts from inflammatory and oxidative injury through EGF/EGFR signaling.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.02.056
Abstract: Epidermal growth factor (EGF)/EFG receptor (EGFR) signaling plays an important role in the osteoblastogenesis. The potential effects of pilose antler peptide (PAP) on osteoblast cell damages was investigated in our present study through EGF/EGFR signaling.… read more here.
Keywords: pilose antler; factor; egfr signaling; egf egfr ... See more keywords
Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100026
Abstract: Abstract Epidermal growth factor receptor (EGFR) signaling drives the formation of many types of cancer, including colon cancer. Docosahexaenoic acid (DHA, 22∶6Δ4,7,10,13,16,19), a chemoprotective long-chain n-3 polyunsaturated fatty acid suppresses EGFR signaling. However, the mechanism… read more here.
Keywords: egfr signaling; factor receptor; growth factor; membrane therapy ... See more keywords
Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-017-0030-1
Abstract: Members of the CD44 family of transmembrane glycoproteins control cell signaling pathways from numerous cell surface receptors, including receptor tyrosine kinases (RTKs). The decisive factor (ligand, RTKs or both) that controls the recruitment of specific… read more here.
Keywords: cd44 isoforms; recruitment; egfr signaling; breast cancer ... See more keywords
A simple toolset to identify endogenous post-translational modifications for a target protein: a snapshot of the EGFR signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20170919
Abstract: Identification of a novel post-translational modification (PTM) for a target protein, defining its physiologic role and studying its potential cross-talk with other PTMs is a challenging process. A set of highly sensitive tools termed as… read more here.
Keywords: egfr signaling; post translational; target protein; signaling pathway ... See more keywords