Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.
Sign Up to like & getrecommendations! Published in 2021 at "Nature cell biology"
DOI: 10.1038/s41556-021-00639-4
Abstract: Activated EGFR signalling drives tumorigenicity in 50% of glioblastoma (GBM). However, EGFR-targeting therapy has proven ineffective in treating patients with GBM, indicating that there is redundant EGFR activation. Circular RNAs are covalently closed RNA transcripts… read more here.
Keywords: egfr signalling; rna; cad; activation ... See more keywords
Polarization of ADAM17‐driven EGFR signalling in electric field‐guided collective migration of epidermal sheets
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DOI: 10.1111/jcmm.16019
Abstract: Endogenous electric field is considered to play an important role in promoting collective migration of epidermis to the wound centre. However, most studies are focused on the effect of bioelectric field on the movement and… read more here.
Keywords: egfr signalling; migration; migration epidermal; collective migration ... See more keywords
Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16135
Abstract: Dysfunction of epidermal growth factor receptor (EGFR) signalling plays a critical role in the oncogenesis of non–small‐cell lung cancer (NSCLC). Here, we reported the natural product, licochalcone A, exhibited a profound anti‐tumour efficacy through directly… read more here.
Keywords: licochalcone; egfr signalling; nsclc cells; cancer ... See more keywords