PACAP through EGFR transactivation preserves human corneal endothelial integrity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28293
Abstract: The corneal endothelium is composed of a single hexagonal‐shaped cells layer adherent to the Descemet's membrane. The primary function of these cells is maintaining of tissue clarity by regulating its hydration. Trauma, aging or other… read more here.
Keywords: pacap; corneal endothelial; egfr transactivation; endothelial integrity ... See more keywords
BRET‐based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein‐independent activation and AT1R‐EGFR complexes
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.017
Abstract: &NA; The type 1 angiotensin II (AngII) receptor (AT1R) transactivates the epidermal growth factor receptor (EGFR), which leads to pathological remodeling of heart, blood vessels and kidney. End‐point assays are used as surrogates of EGFR… read more here.
Keywords: egfr; at1r; at1r egfr; egfr transactivation ... See more keywords