Innovative Pyrazole–Thiazole–Oxadiazole Hybrid Compounds for Targeted EGFR/VEGFR2 Inhibition in Cancer Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70122
Abstract: A new series of pyrazole–thiazole–oxadiazole hybrid compounds targeting the EGFR and VEGFR2 enzymes was designed and synthesized using innovative approaches. The compounds were characterized through spectral methods, and their cytotoxic activities were evaluated against the… read more here.
Keywords: cancer; pyrazole thiazole; inhibition; oxadiazole hybrid ... See more keywords
Combined experimental and computational investigation of vildagliptin: spectroscopy, electronic structure, MD and Docking to EGFR, VEGFR2, and HER2 anticancer targets
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-025-00646-9
Abstract: This study combines experimental and computational approaches to investigate the molecular geometry and physicochemical properties of vildagliptin (VILD). Using methods such as UV-Vis, spectrofluorimetry, FTIR/Raman, and circular dichroism alongside DFT, molecular docking, and dynamics simulations,… read more here.
Keywords: spectroscopy; vegfr2 her2; anticancer; experimental computational ... See more keywords
Interactions between ligand-bound EGFR and VEGFR2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167006
Abstract: In this work, we put forward the provocative hypothesis that the active, ligand-bound RTK dimers from unrelated subfamilies can associate into heterooligomers with novel signaling properties. This hypothesis is based on a quantitative FRET study… read more here.
Keywords: egfr vegfr2; presence; interactions ligand; bound egfr ... See more keywords