Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strain.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.05.086
Abstract: Human influenza viruses passaged in eggs often acquire mutations in the hemagglutinin (HA) receptor binding site (RBS). To determine if egg-adapted H1N1 vaccines commonly elicit antibodies targeting the egg-adapted RBS of HA, we completed hemagglutinin-inhibition… read more here.
Keywords: egg adapted; hemagglutinin receptor; binding site; egg ... See more keywords
Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1712377114
Abstract: Significance The majority of influenza vaccine antigens are prepared in chicken eggs. Human vaccine strains grown in eggs often possess adaptive mutations that increase viral attachment to chicken cells. Most of these adaptive mutations are… read more here.
Keywords: glycosylation site; vaccine; h3n2; egg adapted ... See more keywords
Isolation of an Egg-Adapted Influenza A(H3N2) Virus without Amino Acid Substitutions at the Antigenic Sites of Its Hemagglutinin.
Sign Up to like & getrecommendations! Published in 2018 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2017.551
Abstract: Antigenic changes in the hemagglutinin protein of recent A(H3N2) viruses often arise when these viruses adapt to their egg host. By serial egg passages of a cell-propagated virus, we successfully isolated an egg-adapted influenza A(H3N2)… read more here.
Keywords: egg adapted; h3n2 virus; egg; influenza h3n2 ... See more keywords