H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2321859121
Abstract: Significance Repetitive DNA sequences in the genome can cause problems for our cells. To protect the genome, cells turn off these repetitive sequences by placing them in inactive heterochromatic areas and adding repressive markers. However,… read more here.
Keywords: eggless setdb1; facilitates reinstallation; repetitive sequences; h3k14ac facilitates ... See more keywords
Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201948296
Abstract: Eggless/SETDB1 (Egg), the only essential histone methyltransferase (HMT) in Drosophila, plays a role in gene repression, including piRNA‐mediated transposon silencing in the ovaries. Previous studies suggested that Egg is post‐translationally modified and showed that Windei… read more here.
Keywords: monoubiquitination; transposon silencing; egg; eggless setdb1 ... See more keywords