A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor.
Sign Up to like & getrecommendations! Published in 2023 at "Genesis"
DOI: 10.1002/dvg.23515
Abstract: Early growth response 1 (EGR1) mediates transcriptional programs that are indispensable for cell division, differentiation, and apoptosis in numerous physiologies and pathophysiologies. Whole-body EGR1 knockouts in mice (Egr1KO ) have advanced our understanding of EGR1… read more here.
Keywords: growth response; crispr cas9; early growth; mouse ... See more keywords
lnc003875/miR-363/EGR1 regulatory network in the carcinoma -associated fibroblasts controls the angiogenesis of human placental site trophoblastic tumor (PSTT).
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111783
Abstract: The rare gestational trophoblastic neoplasia placental site trophoblastic tumor (PSTT) frequently demonstrates a high degree of vascularization, which may facilitate the tumor metastasis. However, the underlying mechanisms remain largely unknown. In the present study, we… read more here.
Keywords: egr1; placental site; pstt; mir 363 ... See more keywords
Neuroprotective microRNA-381 Binds to Repressed Early Growth Response 1 (EGR1) and Alleviates Oxidative Stress Injury in Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00724
Abstract: As a common and disabling disease of the elderly, the standard therapies of Parkinson's disease (PD) fail to curb the ongoing neurodegeneration, thus calling for newer strategies. This work was conducted to examine the effect… read more here.
Keywords: parkinson disease; oxidative stress; egr1; mir 381 ... See more keywords
miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-65373-x
Abstract: Ischemic heart diseases are a major global cause of death, and despite timely revascularization, heart failure due to ischemia-hypoxia reperfusion (IH/R) injury remains a concern. The study focused on the role of Early Growth Response… read more here.
Keywords: hypoxia reperfusion; ischemia hypoxia; reperfusion injury; egr1 ... See more keywords
Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07531-z
Abstract: Acute lung injury (ALI), a frequent and severe complication of sepsis, is associated with significant mortality rates. Previous studies indicated that GLS2 plays a key role in promoting ferroptosis. However, its underlying mechanisms remain unclear.… read more here.
Keywords: lung injury; gls2; egr1; acute lung ... See more keywords
EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway
Sign Up to like & getrecommendations! Published in 2024 at "Virulence"
DOI: 10.1080/21505594.2024.2435374
Abstract: ABSTRACT Candida albicans is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, C. albicans invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via… read more here.
Keywords: egr1 regulates; candida albicans; oral epithelial; egr1 ... See more keywords
Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4646
Abstract: While extracellular matrix (ECM) mechanics strongly regulate stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural… read more here.
Keywords: stem cell; egr1; lineage commitment; matrix specific ... See more keywords
High expression of transcription factor EGR1 is associated with postoperative muscle atrophy in patients with knee osteoarthritis undergoing total knee arthroplasty
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-024-05109-9
Abstract: Muscle atrophy is a typical affliction in patients affected by knee Osteoarthritis (KOA). This study aimed to examine the potential pathogenesis and biomarkers that coalesce to induce muscle atrophy, primarily through the utilization of bioinformatics… read more here.
Keywords: muscle; muscle atrophy; analysis; egr1 ... See more keywords
miR-191-5p attenuates TNF-α-induced inflammation in nucleus pulposus cells via targeting EGR1
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-025-06327-5
Abstract: Intervertebral disc degeneration (IVDD) is an orthopedic degenerative disease characterized by low back pain, the pathogenesis of which remains inadequately understood. Recent research has illuminated a potential link between dysregulation of microRNAs (miRNAs) and the… read more here.
Keywords: egr1; cell; mir 191; nucleus pulposus ... See more keywords
Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of cell science"
DOI: 10.1242/jcs.261825
Abstract: Some chemotherapy drugs modulate the formation of stress granules (SGs), which are RNA-containing cytoplasmic foci contributing to stress response pathways. How SGs mechanistically contribute to pro-survival or pro-apoptotic functions must be better defined. The chemotherapy… read more here.
Keywords: mrnas; stress granule; lomustine induced; stress ... See more keywords
EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002034
Abstract: The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. TFEB is regulated at the posttranslational level by the nutrient-sensitive kinase… read more here.
Keywords: tfeb; tfeb transcription; egr1; response starvation ... See more keywords