A CRISPR/Cas9-engineered mouse carrying a conditional knockout allele for the early growth response-1 transcription factor.
Sign Up to like & getrecommendations! Published in 2023 at "Genesis"
DOI: 10.1002/dvg.23515
Abstract: Early growth response 1 (EGR1) mediates transcriptional programs that are indispensable for cell division, differentiation, and apoptosis in numerous physiologies and pathophysiologies. Whole-body EGR1 knockouts in mice (Egr1KO ) have advanced our understanding of EGR1… read more here.
Keywords: growth response; crispr cas9; early growth; mouse ... See more keywords
lnc003875/miR-363/EGR1 regulatory network in the carcinoma -associated fibroblasts controls the angiogenesis of human placental site trophoblastic tumor (PSTT).
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111783
Abstract: The rare gestational trophoblastic neoplasia placental site trophoblastic tumor (PSTT) frequently demonstrates a high degree of vascularization, which may facilitate the tumor metastasis. However, the underlying mechanisms remain largely unknown. In the present study, we… read more here.
Keywords: egr1; placental site; pstt; mir 363 ... See more keywords
Neuroprotective microRNA-381 Binds to Repressed Early Growth Response 1 (EGR1) and Alleviates Oxidative Stress Injury in Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00724
Abstract: As a common and disabling disease of the elderly, the standard therapies of Parkinson's disease (PD) fail to curb the ongoing neurodegeneration, thus calling for newer strategies. This work was conducted to examine the effect… read more here.
Keywords: parkinson disease; oxidative stress; egr1; mir 381 ... See more keywords
Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4646
Abstract: While extracellular matrix (ECM) mechanics strongly regulate stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural… read more here.
Keywords: stem cell; egr1; lineage commitment; matrix specific ... See more keywords
EGR1 drives cell proliferation by directly stimulating TFEB transcription in response to starvation
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002034
Abstract: The stress-responsive transcription factor EB (TFEB) is a master controller of lysosomal biogenesis and autophagy and plays a major role in several cancer-associated diseases. TFEB is regulated at the posttranslational level by the nutrient-sensitive kinase… read more here.
Keywords: tfeb; tfeb transcription; egr1; response starvation ... See more keywords
Egr1 is necessary for forebrain dopaminergic signaling during social behavior.
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0035-22.2022
Abstract: Finding the link between behaviors and their regulatory molecular pathways is a major obstacle in treating neuropsychiatric disorders. The immediate early gene EGR1 is implicated in the etiology of neuropsychiatric disorders, and is linked to… read more here.
Keywords: neuropsychiatric disorders; signaling social; social behavior; behavior ... See more keywords
Influence of the Klotho/FGF23/Egr1 signaling pathway on calcium-phosphorus metabolism in diabetic nephropathy and the intervention of Shenyuan granules.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biological regulators and homeostatic agents"
DOI: 10.23812/19-207-a
Abstract: This study aimed to explore the effects of Shenyuan granules on the Klotho/FGFR23/Egr1 signaling pathway and calcium-phosphorus metabolism in diabetic mice models with impairment of renal function. Streptozotocin-induced diabetic nephropathy (DN) mice models were randomly… read more here.
Keywords: shenyuan granules; egr1; group; calcium phosphorus ... See more keywords
Detecting Abnormal Neuronal Activity in a Chronic Migraine Model by Egr1-EGFP Transgenic Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.705938
Abstract: Chronic migraine (CM) is a highly disabling neurological disorder characterized by recurrent headache accompanied by a variety of sensory and/or emotional symptoms. However, the mechanisms of migraine onset and its chronicity have not been elucidated.… read more here.
Keywords: egr1; transgenic mice; chronic migraine; egfp transgenic ... See more keywords
The Effect of EGR1 on the Proliferation of Dermal Papilla Cells
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13071242
Abstract: Early growth response factor 1 (EGR1) is a zinc-finger transcription factor that plays a vital role in the development of hair follicles. According to our previous studies, EGR1 is a transcriptional promoter of the bone… read more here.
Keywords: effect; papilla cells; dermal papilla; hair ... See more keywords
Novel Pituitary Actions of Epidermal Growth Factor: Receptor Specificity and Signal Transduction for UTS1, EGR1, and MMP13 Regulation by EGF
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20205172
Abstract: Epidermal growth factor (EGF) is a member of the EGF-like ligands family, which plays a vital role in cell proliferation, differentiation, and folliculogenesis through binding with EGF receptors, including ErbB1 (EGFR/HER1), ErbB2 (HER2), ErbB3 (HER3),… read more here.
Keywords: egr1; uts1 egr1; mmp13; epidermal growth ... See more keywords
Transcriptional Regulation of GDF15 by EGR1 Promotes Head and Neck Cancer Progression through a Positive Feedback Loop
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222011151
Abstract: Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β (TGF-β) superfamily, has been reported to be overexpressed in different kinds of cancer types. However, the function and mechanism of GDF15… read more here.
Keywords: hnc; egr1; gdf15; gdf15 egr1 ... See more keywords