The eIg technology to generate Ig-like bispecific antibodies
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2063043
Abstract: ABSTRACT Bispecific antibodies have emerged as therapeutic molecules with a multitude of modes of action and applications. Here, we present a novel approach to solve the light-chain problem for the generation of bispecific Ig-like antibodies… read more here.
Keywords: chain; ehd2; receptor; domain ... See more keywords
EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.21.497035
Abstract: With nearly all cancer deaths a result of metastasis, elucidating novel pro-metastatic cellular adaptations could provide new therapeutic targets. Here, we show that overexpression of the EPS15-Homology Domain-containing 2 (EHD2) protein in a large subset… read more here.
Keywords: metastasis; ehd2; breast; triple negative ... See more keywords
EHD2 inhibits the invasive ability of lung adenocarcinoma and improves the prognosis of patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-22-842
Abstract: Background EH domain contains protein 2 (EHD2) may be involved in tumorigenesis and development. However, the role of EHD2 in lung adenocarcinoma (LUAD) is unknown. Methods The link between EHD2 and LUAD and the associated… read more here.
Keywords: prognosis; ehd2; lung adenocarcinoma; expression ... See more keywords
TUSC8 inhibits the development of osteosarcoma by sponging miR-197-3p and targeting EHD2
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4684
Abstract: Osteosarcoma (OS) is one of the most common malignant bone tumours and generally occurs in children and adolescents. Increasing evidence has demonstrated that dysregulated long non-coding RNAs (lncRNAs) play crucial roles in the progression of… read more here.
Keywords: inhibits development; ehd2; development osteosarcoma; mir 197 ... See more keywords