Targeting EHMT2/ G9a for cancer therapy: progress and perspective.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173827
Abstract: Euchromatic histone lysine methyltransferase-2, also known as G9a, is a ubiquitously expressed SET domain-containing histone lysine methyltransferase linked with both facultative and constitutive heterochromatin formation and transcriptional repression. It is an essential developmental gene and… read more here.
Keywords: targeting ehmt2; ehmt2 g9a; cancer therapy; cancer ... See more keywords
Human EHMT2/G9a activates p53 through methylation-independent mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.258
Abstract: p53 is a critical tumor suppressor in humans. It functions mostly as a transcriptional factor and its activity is regulated by numerous post-translational modifications. Among different covalent modifications found on p53 the most controversial one… read more here.
Keywords: methylation; ehmt2 g9a; human ehmt2; hg9a ... See more keywords