Ehrlichia chaffeensis and E. canis hypothetical protein immunoanalysis reveals small secreted immunodominant proteins and conformation-dependent antibody epitopes
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Vaccines"
DOI: 10.1038/s41541-020-00231-1
Abstract: Immunomolecular characterization of Ehrlichia chaffeensis (E. ch.) and E. canis (E. ca.) has defined protein orthologs, including tandem repeat proteins (TRPs) that have immunodominant linear antibody epitopes. In this study, we combined bioinformatic analysis and… read more here.
Keywords: antibody epitopes; antibody; chaffeensis canis; ehrlichia chaffeensis ... See more keywords
Human Case of Ehrlichia chaffeensis Infection, Taiwan
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DOI: 10.3201/eid2511.190665
Abstract: In 2018, an immunosuppressed woman in southern Taiwan had onset of fever, chills, myalgia, malaise, thrombocytopenia, lymphocytopenia, and elevated hepatic transaminases. Investigation revealed infection with Ehrlichia chaffeensis. This autochthonous case of human monocytotropic ehrlichiosis was… read more here.
Keywords: human case; infection; case ehrlichia; ehrlichia chaffeensis ... See more keywords
The “Biological Weapons” of Ehrlichia chaffeensis: Novel Molecules and Mechanisms to Subjugate Host Cells
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DOI: 10.3389/fcimb.2021.830180
Abstract: Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging, potentially fatal tick-borne infectious disease. The bacterium enters human cells via the binding of its unique outer-membrane invasin EtpE to the… read more here.
Keywords: chaffeensis; ehrlichia chaffeensis; host cells; host ... See more keywords
Antigen-Specific CD4+CD8+ Double-Positive T Cells Are Increased in the Blood and Spleen During Ehrlichia chaffeensis Infection in the Canine Host
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DOI: 10.3389/fimmu.2018.01585
Abstract: Ehrlichia chaffeensis is an obligate intracellular bacterium belonging to the order, Rickettsiales and is a frequent cause of severe and fatal tick-borne infection in people in North America. The reservoir host for E. chaffeensis is… read more here.
Keywords: canine; infection; chaffeensis; chaffeensis infection ... See more keywords
Glutathione Synthesis Regulated by CtrA Protects Ehrlichia chaffeensis From Host Cell Oxidative Stress
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DOI: 10.3389/fmicb.2022.846488
Abstract: Ehrlichia chaffeensis, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses. Reactive oxygen species are produced by the host immune… read more here.
Keywords: ehrlichia chaffeensis; chaffeensis; gsha gshb; oxidative stress ... See more keywords