Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine
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DOI: 10.1021/acsomega.1c00772
Abstract: Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for the treatment of COVID-19. Herein, we describe a supply-centered and chromatography-free synthesis of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation… read more here.
Keywords: molnupiravir 4482; molnupiravir; synthesis molnupiravir; 4482 eidd ... See more keywords
SARS-CoV-2 Infection is Effectively Treated and Prevented by EIDD-2801
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DOI: 10.1038/s41586-021-03312-w
Abstract: Summary Paragraph All known recently emerged human coronaviruses likely originated in bats1. Here, we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged… read more here.
Keywords: infection; human lung; eidd 2801; sars cov ... See more keywords
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
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DOI: 10.1126/scitranslmed.aax5866
Abstract: A next-generation, broad-spectrum, orally efficacious influenza A and B virus inhibitor is associated with a high genetic resistance barrier. Treating flu, escaping resistance Influenza viruses can cause severe illness and death. Although vaccines are continuously… read more here.
Keywords: influenza; resistance; human airway; eidd 2801 ... See more keywords