Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2120339119
Abstract: Significance eIF4G1 interacts with eIF4E and eIF1 in a mutually exclusive manner. Using a high-throughput drug screen, the eIF1–eIF4G1 inhibitors, named i14G1s, were identified. The i14G1s established the importance of eIF4G1 cooperation with eIF1 in… read more here.
Keywords: response genes; eif4g1; stress response; eif1 ... See more keywords
Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00139-18
Abstract: Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning, except for mRNAs bearing the translation initiator of short 5′… read more here.
Keywords: eif4g1; initiation; translation; eif1 ... See more keywords