LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "eif2" as a keyword



PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.

Sign Up to like & get
recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.012

Abstract: Metabolic reprogramming is emerging as a key pathological contributor to the progression of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying dysregulated cellular metabolism remain elusive. Here we report that amino acid… read more here.

Keywords: eif2 atf4; eif2; amino acid; acid biosynthesis ... See more keywords

The phosphorylation of carboxyl-terminal eIF2α by SPA kinases contributes to enhanced translation efficiency during photomorphogenesis

Sign Up to like & get
recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-47848-7

Abstract: Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) at a conserved serine residue… read more here.

Keywords: eif2; phosphorylation; translation; photomorphogenesis ... See more keywords
Photo from wikipedia

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway

Sign Up to like & get
recommendations! Published in 2021 at "International Journal of Endocrinology"

DOI: 10.1155/2021/5038130

Abstract: The protein-kinase-R- (PKR-) like endoplasmic reticulum kinase (PERK) signaling pathway is a well-known promoter of cell apoptosis. In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor… read more here.

Keywords: eif2 atf4; eif2; atf4 signaling; perk eif2 ... See more keywords

A Novel eIF2α-Phosphorylating Agent HR-19011 Exhibits Cell Growth Inhibitory Effects in K562 Cells through Hri Activation

Sign Up to like & get
recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-209798

Abstract: Targeted therapy exploits the unique molecular vulnerabilities of cancer cells and typically alters cellular signaling pathways to inhibit tumor growth and promote cell death. However, despite the successful application of these agents in the treatment… read more here.

Keywords: k562 cells; cell growth; eif2; growth ... See more keywords

Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling

Sign Up to like & get
recommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2022.916458

Abstract: Objective Cisplatin is a broad-spectrum anti-tumour drug commonly used in clinical practice. However, its ototoxicity greatly limits its clinical application, and no effective method is available to prevent this effect. Endoplasmic reticulum stress (ERS) is… read more here.

Keywords: endoplasmic reticulum; cell; hair; eif2 ... See more keywords

The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24098064

Abstract: Fluorizoline is a synthetic molecule that induces apoptosis, by selectively targeting prohibitins (PHBs), through induction of the BH3-only protein NOXA. This induction is transcriptionally regulated by the integrated stress response (ISR)-related transcription factors ATF3 and… read more here.

Keywords: stress response; kinase; eif2; integrated stress ... See more keywords

Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species

Sign Up to like & get
recommendations! Published in 2025 at "Vaccines"

DOI: 10.3390/vaccines13080800

Abstract: Background: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2). PKR also modulates NF-κB signaling during viral infections, but comparative studies of PKR-mediated NF-κB… read more here.

Keywords: eif2; pkr; translation; pkr orthologs ... See more keywords

Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

Sign Up to like & get
recommendations! Published in 2017 at "eLife"

DOI: 10.7554/elife.24542

Abstract: Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). This modulates the expression of all eukaryotic mRNAs and contributes to the cellular integrated stress response. Key to controlling… read more here.

Keywords: ternary complexes; eif2; eif2 gtp; translation ... See more keywords