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   Articles with "eif2 atf4" as a keyword



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Maduramicin ammonium impairs autophagic flux through activating AMPK-mediated eIF2α-ATF4 endoplasmic reticulum stress pathway in skeletal muscle.

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recommendations! Published in 2024 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.14071

Abstract: BACKGROUND Maduramicin ammonium (MA), a widely used coccidiostat, has been reported to cause skeletal muscle degeneration in animals and even humans. In this study, we explore the underlying mechanism of its toxicity in skeletal muscle.… read more here.

Keywords: skeletal muscle; muscle; autophagic flux; eif2 atf4 ... See more keywords

Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK/eIF2α/ATF4/CHOP Signaling Pathway Axis

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recommendations! Published in 2024 at "Environmental Toxicology"

DOI: 10.1002/tox.24376

Abstract: The clinical application of polymyxin B (PMB) is limited by its nephrotoxic effects, making the reduction of PMB‐induced nephrotoxicity has become a pressing concern for clinicians. Tetrahydrocurcumin (THC), known for its beneficial characteristics in biological… read more here.

Keywords: induced nephrotoxicity; stress; eif2 atf4; pmb ... See more keywords

Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway

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recommendations! Published in 2019 at "Neuroscience Bulletin"

DOI: 10.1007/s12264-019-00411-7

Abstract: Apoptosis induced by endoplasmic reticulum (ER) stress plays a crucial role in mediating brain damage after ischemic stroke. Recently, Hes1 (hairy and enhancer of split 1) has been implicated in the regulation of ER stress,… read more here.

Keywords: eif2 atf4; ischemic stroke; apoptosis; perk eif2 ... See more keywords

PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.012

Abstract: Metabolic reprogramming is emerging as a key pathological contributor to the progression of autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying dysregulated cellular metabolism remain elusive. Here we report that amino acid… read more here.

Keywords: eif2 atf4; eif2; amino acid; acid biosynthesis ... See more keywords
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Endoplasmic Reticulum Stress-Activated PERK-eIF2α-ATF4 Signaling Pathway is Involved in the Ameliorative Effects of Ginseng Polysaccharides against Cisplatin-Induced Nephrotoxicity in Mice

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recommendations! Published in 2021 at "ACS Omega"

DOI: 10.1021/acsomega.0c06339

Abstract: Although previous studies have reported that saponins (ginsenosides, the major active and most representative ingredients in Panax ginseng C.A. Meyer) exerted a good ameliorative effect on cisplatin (CP)-induced acute kidney injury in animal models, little… read more here.

Keywords: eif2 atf4; perk eif2; stress; perk ... See more keywords
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Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway

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recommendations! Published in 2021 at "International Journal of Endocrinology"

DOI: 10.1155/2021/5038130

Abstract: The protein-kinase-R- (PKR-) like endoplasmic reticulum kinase (PERK) signaling pathway is a well-known promoter of cell apoptosis. In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor… read more here.

Keywords: eif2 atf4; eif2; atf4 signaling; perk eif2 ... See more keywords

Didang Tang alleviates neuronal ferroptosis after intracerebral hemorrhage by modulating the PERK/eIF2α/ATF4/CHOP/GPX4 signaling pathway

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recommendations! Published in 2024 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2024.1472813

Abstract: Introduction Ferroptosis is a crucial process contributing to neuronal damage following intracerebral hemorrhage (ICH). Didang Tang (DDT), a traditional therapeutic, has been used clinically to manage ICH for many years, yet the molecular mechanisms by… read more here.

Keywords: eif2 atf4; ddt; ferroptosis; perk eif2 ... See more keywords

Protective effects of Salubrinal against H2O2-induced muscle wasting via eIF2α/ATF4 signaling pathway

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recommendations! Published in 2025 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2025.1607606

Abstract: Background Endoplasmic reticulum stress (ERS) plays a critical role in skeletal muscle physiology and pathology, though the precise mechanisms remain unclear. Salubrinal, a selective inhibitor of eIF2α dephosphorylation, has been shown as a potential therapeutic… read more here.

Keywords: effects salubrinal; protective effects; muscle; eif2 atf4 ... See more keywords

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23094479

Abstract: Porcine circovirus 2 (PCV2) and pseudorabies virus (PRV) are two important pathogens in the pig industry. PCV2 or PRV infection can induce endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). However, the effect of… read more here.

Keywords: pcv2; prv coinfection; pcv2 prv; eif2 atf4 ... See more keywords

Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23137196

Abstract: Chronic treatment with acetaminophen (APAP) induces cysteine (Cys) and glutathione (GSH) deficiency which leads to adverse metabolic effects including muscle atrophy. Mammalian cells respond to essential amino acid deprivation through the phosphorylation of the eukaryotic… read more here.

Keywords: supplementation; atf4 pathway; activation eif2; dietary supplementation ... See more keywords

Modulation of GCN2/eIF2α/ATF4 Pathway in the Liver and Induction of FGF21 in Young Goats Fed a Protein- and/or Phosphorus-Reduced Diet

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24087153

Abstract: Mammals respond to amino acid (AA) deficiency by initiating an AA response pathway (AAR) that involves the activation of general control nonderepressible 2 (GCN2), phosphorylation of eukaryotic translation initiation factor 2α (eIF2α), and activation of… read more here.

Keywords: gcn2; fgf21; atf4 pathway; gcn2 eif2 ... See more keywords