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   Articles with "eif2 kinase" as a keyword



Elucidation of molecular mechanism of stability of the heme-regulated eIF2α kinase upon binding of its ligand, hemin in its catalytic kinase domain

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recommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2017.1368417

Abstract: The eIF2α kinase activity of the heme-regulated inhibitor (HRI) is regulated by heme which makes it a unique member of the family of eIF2α kinases. Since heme concentrations create an equilibrium for the kinase to… read more here.

Keywords: heme; kinase; eif2 kinase; stability ... See more keywords

The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

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recommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2017.1397133

Abstract: ABSTRACT Introduction: The eIF2α kinase heme-regulated inhibitor (HRI) is one of four well-described kinases that phosphorylate eIF2α in response to various cell stressors, resulting in reduced ternary complex formation and attenuation of mRNA translation. Although… read more here.

Keywords: kinase; hri; eif2 kinase; kinase hri ... See more keywords
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Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation

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recommendations! Published in 2020 at "PLoS ONE"

DOI: 10.1371/journal.pone.0229948

Abstract: The integrated stress response (ISR) is one of the most important cytoprotective mechanisms and is integrated by phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Four eIF2α kinases, heme-regulated inhibitor (HRI),… read more here.

Keywords: electric fields; response; kinase; eif2 kinase ... See more keywords
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The fifth element: a novel eIF2α kinase in microglia

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recommendations! Published in 2023 at "EMBO Reports"

DOI: 10.15252/embr.202357231

Abstract: The cellular integrated stress response (ISR) is a central signaling pathway that tunes translation initiation in response to a wide range of cellular insults to promote cell survival. The critical node of this regulation involves… read more here.

Keywords: element novel; kinase microglia; novel eif2; fifth element ... See more keywords