An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress Response.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1975-9_1
Abstract: Phosphorylation of the translation initiation factor eIF2α is an adaptive signaling event that is essential for cell and organismal survival from yeast to humans. It is central to the integrated stress response (ISR) that maintains… read more here.
Keywords: stress response; eif2 phosphorylation; phosphorylation; overview methods ... See more keywords
An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances Splicing.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.035
Abstract: Tumor necrosis factor alpha (TNF-α) is expressed promptly during inflammatory responses. Efficient TNF-α mRNA splicing is achieved through a 3' UTR element that activates RNA-dependent eIF2α protein kinase (PKR). The TNF-α RNA activator, we show,… read more here.
Keywords: enhances splicing; potently enhances; mrna splicing; eif2 phosphorylation ... See more keywords
Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aaw6763
Abstract: Doxorubicin-induced DNA damage promotes cancer cell migration downstream of eIF2α phosphorylation. Moved by DNA damage Doxorubicin is a commonly used therapeutic that kills cancer cells by inducing genotoxic stress. Harvey et al. found that, at… read more here.
Keywords: eif2 phosphorylation; cell migration; migration; doxorubicin ... See more keywords
Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193790
Abstract: The regulation of translation initiation factor 2 (eIF2) is important for erythroid survival and differentiation. Lack of iron, a critical component of heme and hemoglobin, activates Heme Regulated Inhibitor (HRI). This results in phosphorylation of… read more here.
Keywords: erythroid; ribosome profiling; mrna translation; translation ... See more keywords
The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2α Phosphorylation and Stress Granule Formation
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v12010039
Abstract: Sindbis virus (SINV) infection induces eIF2α phosphorylation, which leads to stress granule (SG) assembly. SINV infection also stimulates autophagy, which has an important role in controlling the innate immune response. The importance of autophagy to… read more here.
Keywords: phosphorylation; autophagy protein; protein atg16l1; eif2 phosphorylation ... See more keywords