Curcumin Attenuates the PERK-eIF2α Signaling to Relieve Acrylamide-Induced Neurotoxicity in SH‑SY5Y Neuroblastoma Cells
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DOI: 10.1007/s11064-021-03504-w
Abstract: Curcumin is a natural polyphenolic compound with neuroprotective and antioxidant properties. Acrylamide (ACR) is a by-product of food processing that produces neurotoxicity in humans and animals. The pancreatic endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)… read more here.
Keywords: eif2 signaling; sy5y; induced neurotoxicity; acr induced ... See more keywords
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
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DOI: 10.1038/s41380-021-01099-w
Abstract: Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) has been shown to activate the eIF2α kinase PERK to directly regulate translation initiation. Tight control of PERK-eIF2α signaling has been shown to be necessary… read more here.
Keywords: cognitive function; perk; perk eif2; eif2 signaling ... See more keywords
Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling
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DOI: 10.1155/2020/5958272
Abstract: Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and… read more here.
Keywords: metastasis colorectal; colorectal cancer; perk eif2; eif2 signaling ... See more keywords