In vivo evidence that eIF3 stays bound to ribosomes elongating and terminating on short upstream ORFs to promote reinitiation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx049
Abstract: Abstract Translation reinitiation is a gene-specific translational control mechanism characterized by the ability of some short upstream ORFs to prevent recycling of the post-termination 40S subunit in order to resume scanning for reinitiation downstream. Its… read more here.
Keywords: reinitiation; vivo evidence; upstream orfs; short upstream ... See more keywords
eIF3 Interacts with Selenoprotein mRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12091268
Abstract: The synthesis of selenoproteins requires the co-translational recoding of an in-frame UGASec codon. Interactions between the Selenocysteine Insertion Sequence (SECIS) and the SECIS binding protein 2 (SBP2) in the 3′untranslated region (3′UTR) of selenoprotein mRNAs… read more here.
Keywords: selenoprotein mrnas; eif3; translation initiation; eif3 interacts ... See more keywords
Repression of ferritin light chain translation by human eIF3
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.48193
Abstract: A central problem in human biology remains the discovery of causal molecular links between mutations identified in genome-wide association studies (GWAS) and their corresponding disease traits. This challenge is magnified for variants residing in non-coding… read more here.
Keywords: light chain; ferritin light; translation; repression ... See more keywords